Identifying shared and distinct cell type vulnerability across neurological diseases.

PROJECT NARRATIVE Neurodegenerative diseases have differential effects on cell types in the brain, whereby some cells are preferentially vulnerable whereas others seem more robust to the effects of disease pathology. However, there is a gap in our knowledge of which cell type-specific changes are unique to a given disease, and which changes are found in multiple diseases such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Frontotemporal Dementia. This proposal aims to examine post-mortem brain tissue at single-cell resolution to identify shared and disease-specific signatures across this range of neurodegenerative disorders.