Macromolecular dynamics and conformational changes in biological function

The present proposal addresses the coupling between structure, dynamics, and function of biological macromolecules, including proteins and nucleic acids, involved in fundamental biological processes, including folding, recognition, allostery, regulation and catalysis. Elaboration of the roles of conformational dynamics in actuating and regulating these processes is essential for understanding the fundamental functions of biological macromolecules in human health and disease.