Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival

Project Narrative The proposal describes an inter-disciplinary project whose goal is to systematically determine the role of RNA- binding proteins (a set of cellular regulatory proteins that recognize, bind, and regulate mRNAs) in the process of cancer progression. Our preliminary data suggests that these regulators play a disproportionately important role in cancer and our project is a multi-faceted computational/experimental strategy to characterize this landscape. If successful, the project will expand our understanding of cancer pathways in novel directions that may have significant impact on diagnosis and treatment of a variety of cancers.