Mechanistic Monitoring of Ultrasound Neuromodulation

Central Nervous System diseases affect several millions of patients in the U.S. Current drug treatments are often associated with side-effects. Neuromodulation can be achieved either with noninvasive techniques that are depth limited or invasive procedures that can go to large depths. Focused ultrasound offers the unique alternative of modulating deep-seated structures noninvasively. In this study, we will develop novel tools to assess ultrasound modulation by monitoring the effects of ultrasound on brain tissue.