Preclinical analyses of advanced prostate cancer in genetically-engineered mice

Project Narrative Despite recent advances in new treatments, most men with advanced prostate cancer succumb to the disease. The major causes of prostate cancer deaths are due to failed response to treatment and metastasis, particularly to bone. Our proposal takes an innovative approach to address these clinical challenges by studying treatment response in the whole organism using genetically-engineered mouse models (GEMMs) with validation to human prostate cancer, in order to optimize drugs/drug combinations for: (1) treatment-induced aggressive castration-resistant prostate cancer; and (2) lethal bone metastasis.