RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGe

Unconsciousness is common after acute brain injury such as a brain hemorrhage, and recovery is poorly understood. This lack of knowledge is a key impediment to the development of novel strategies to improve outcomes, and is one of the main reasons that prognostication of recovery of consciousness and functional outcomes is inaccurate. One fifth of clinically unconscious patients with acute brain injury are able to follow commands using a simple, bedside EEG motor imagery test that directly measures brain activity associated with the attempt to move. This state is called cognitive motor dissociation (CMD). Pilot data indicates that CMD patients are more likely to clinically recover consciousness and have better long-term functional outcomes than non-CMD patients. To integrate these findings into clinical practice we need to better understand the trajectory of CMD. This will only be possible in a tightly-controlled study with a homogenous patient cohort that is well characterized early after the injury and captures long-term outcomes. The over-arching hypothesis of this application is that once confounders are accounted for, recovery of consciousness follows a predictable course with CMD (diagnosed by an EEG motor imagery paradigm) being a transitory state from unconsciousness to emergence of consciousness. Characterizing the trajectory of recovery will be the overall goal of this application. We propose a two-center, observational cohort study of patients presenting with primary intracerebral hemorrhage (ICH) in the frontal lobe, thalamus, or striatocapsular region who do not have major bleeding in other regions (e.g., midbrain). We will divide ICH patients into two cohorts- conscious and unconscious. In the unconscious cohort, we will determine the time from injury to clinical command following with time to CMD as a time-varying covariate (Aim 1), and determine if CMD predicts long-term functional outcome (Aim 2). In the conscious cohort we will determine if patients with sensory aphasia are able to show command following when tested with the EEG motor imagery paradigm (Aim 3). To answer questions posed in Aims 1 and 2, we will study ICH patients that are unresponsive to commands. We will determine if location and volume of ICH and electrophysiological features on resting EEG are associated with time to CMD. We will determine if CMD independently predicts 6-month modified Rankin Scale after controlling for known predictors. To address Aim 3 we will study conscious ICH patients with and without sensory aphasia using the EEG motor imagery paradigm. This project will determine if CMD is a state that patients predictably transition through as they recover from an unconscious to a conscious state and quantify the false negative rate for command following in aphasic patients. These insights will fill an important gap in the understanding of impairment and recovery of consciousness of this common form of stroke that will likely be generalizable to other brain injuries.