Role of CREBBP missense mutations in lymphomagenesis

RESEARCH NARRATIVE Follicular lymphoma and diffuse large B-cell lymphoma represent the two most common forms of human B cell lymphoma and remain incurable in a significant fraction of patients. This research proposal seeks to elucidate how missense mutations of the CREBBP acetyltransferase, the second most frequent genetic alteration in these tumors, contribute to malignant transformation by reprogramming the pre-neoplastic germinal center B cells as well as the immune microenvironment. The outcome of these studies is expected to further our understanding of the biology of these common cancers and to pave the basis for the development of improved biomarkers and therapeutic approaches.