Role of the Rett Syndrome-causing gene MeCP2 in 3D chromosomal organization and rescue of cellular disease phenotypes

Project Narrative: The proposed research is relevant to public health because it focuses on discovery of the novel role of MeCP2 of which mutations cause Rett Syndrome, the second most common cause of intellectual disability in females whereas male patients are normally more severely affected and die early. These studies will establish new avenues of investigation to develop improved therapeutics to treat this disease. Thus, the proposed research is relevant to NIMH's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with neurological disorders.