Stem Cell Repair of Native Hearts in LVAD Patients

  • Rose, Eric A. (PI)

Projet

Détails sur le projet

Description

Specific Aim 1: To perform a prospective, randomized, placebo-controlled trial to evaluate efficacy of intracoronary autologous bone marrow-derived angioblasts on native heart function in LVAD recipients awaiting cardiac transplantation. Secondary end-points include measurement of neovascularization and cardiac regeneration in explanted native hearts, and determining whether a correlation exists between age and reduced numbers of mobilized bone marrow stem cells. Specific Aim 2: To identify the influence of adult bone marrow-derived angioblasts on mesenchymal stem cell migration, survival, proliferation and differentiation in vitro. Specific Aim 3: To determine if co-transplantation of angioblasts together with autologous mesenchymal stem cells enhances engraftment, myogenesis, and cardiac function in vivo after acute myocardial ischemia.
StatutTerminé
Date de début/de fin réelle1/1/053/31/09

Financement

  • National Heart, Lung, and Blood Institute: 811 092,00 $ US
  • National Heart, Lung, and Blood Institute: 816 675,00 $ US
  • National Heart, Lung, and Blood Institute: 625 160,00 $ US
  • National Heart, Lung, and Blood Institute: 809 389,00 $ US

Keywords

  • Biotecnología

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