Projets par année
Détails sur le projet
Description
Specific Aim 1: To perform a prospective, randomized, placebo-controlled trial to evaluate efficacy of intracoronary autologous bone marrow-derived angioblasts on native heart function in LVAD recipients awaiting cardiac transplantation. Secondary end-points include measurement of neovascularization and cardiac regeneration in explanted native hearts, and determining whether a correlation exists between age and reduced numbers of mobilized bone marrow stem cells. Specific Aim 2: To identify the influence of adult bone marrow-derived angioblasts on mesenchymal stem cell migration, survival, proliferation and differentiation in vitro. Specific Aim 3: To determine if co-transplantation of angioblasts together with autologous mesenchymal stem cells enhances engraftment, myogenesis, and cardiac function in vivo after acute myocardial ischemia.
Statut | Terminé |
---|---|
Date de début/de fin réelle | 1/1/05 → 3/31/09 |
Financement
- National Heart, Lung, and Blood Institute: 811 092,00 $ US
- National Heart, Lung, and Blood Institute: 816 675,00 $ US
- National Heart, Lung, and Blood Institute: 625 160,00 $ US
Keywords
- Biotecnología
Empreinte numérique
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Projets
- 1 Terminé
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Biology of Long-Term Mechanical Circulatory Support
Rose, E. (PI) & Chen, J. (CoPI)
National Heart, Lung, and Blood Institute
2/25/05 → 3/31/10
Projet