Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.

PROJECT NARRATIVE TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly expressed in the skin and implicated in cutaneous sensation, including thermo-sensation, nociception, and itch, in addition to maintenance of the skin barrier, wound healing, and hair growth. The dysfunction of TRPV3 channels, often a result of genetic mutations, is associated with numerous human skin diseases, including a genodermatosis known as Olmsted syndrome, atopic dermatitis, and rosacea. Our goal is to study TRPV3 channels using a combination of biophysical and biochemical techniques and to obtain detailed information about their structure and function that will help develop new drug design strategies.