The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma

PROJECT NARRATIVE Deaths from esophageal adenocarcinoma continue to rise, yet factors driving this trend remain poorly understood. We hope to demonstrate that the inter-relationship between gastro-esophageal reflux bile acid composition, Notch signaling activity, and esophageal bacterial composition is key to driving esophageal neoplasia. This knowledge can in turn be translated to future efforts to modify these factors to prevent esophageal cancer.