The STK25 Signaling Pathway in Human Cardiac Cells

Project Narrative Cardiovascular disease is the leading cause of death worldwide and new therapies are needed to treat this very prevalent disease. We have identified a protein called STK25 that promotes the a metabolic signaling pathway that we believe has significant potential to improve the function of the heart. This proposal seeks to understand how STK25 activates that metabolic pathway and to show that regulation of that pathway has a meaningful effect on cardiovascular biology using tissue engineered models of human myocardium.