A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells

Olimpo García-Beltrán; Natalia Mena; Tania A. Berríos; Enrique A. Castro; Bruce K. Cassels; Marco T. Núñez; Margarita E. Aliaga

doi:10.1016/j.tetlet.2012.09.111

A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells

Olimpo García-Beltrán, Natalia Mena, Tania A. Berríos, Enrique A. Castro, Bruce K. Cassels, Marco T. Núñez, Margarita E. Aliaga

Olimpo

Résultat de recherche › examen par les pairs

22 Citations (Scopus)

Résumé

In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl) propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg ²⁺) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg ²⁺. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells.

Langue d'origine	English
Pages (de-à)	6598-6601
Nombre de pages	4
Journal	Tetrahedron Letters
Volume	53
Numéro de publication	48
DOI	https://doi.org/10.1016/j.tetlet.2012.09.111
Statut de publication	Published - nov. 28 2012

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Bailleurs de fonds	Numéro du bailleur de fonds
Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica	11090115

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2012.09.111

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García-Beltrán, O., Mena, N., Berríos, T. A., Castro, E. A., Cassels, B. K., Núñez, M. T., & Aliaga, M. E. (2012). A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells. Tetrahedron Letters, 53(48), 6598-6601. https://doi.org/10.1016/j.tetlet.2012.09.111

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title = "A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells",

abstract = "In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl) propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg 2+) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg 2+. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells.",

author = "Olimpo Garc{\'i}a-Beltr{\'a}n and Natalia Mena and Berr{\'i}os, {Tania A.} and Castro, {Enrique A.} and Cassels, {Bruce K.} and N{\'u}{\~n}ez, {Marco T.} and Aliaga, {Margarita E.}",

note = "Funding Information: This work was supported by the Millennium Scientific Initiative (Grant P05-001-F ) and by Fondecyt Grant # 11090115 . The authors are grateful to Prof. Frank H. Quina for the use of spectroscopic facilities in the Institute of Chemistry and the USP Research Consortium for Photochemical Technology (NAP-PhotoTech), University of S{\~a}o Paulo, S{\~a}o Paulo, Brazil. ",

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doi = "10.1016/j.tetlet.2012.09.111",

language = "English",

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T1 - A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells

AU - García-Beltrán, Olimpo

AU - Mena, Natalia

AU - Berríos, Tania A.

AU - Castro, Enrique A.

AU - Cassels, Bruce K.

AU - Núñez, Marco T.

AU - Aliaga, Margarita E.

N1 - Funding Information: This work was supported by the Millennium Scientific Initiative (Grant P05-001-F ) and by Fondecyt Grant # 11090115 . The authors are grateful to Prof. Frank H. Quina for the use of spectroscopic facilities in the Institute of Chemistry and the USP Research Consortium for Photochemical Technology (NAP-PhotoTech), University of São Paulo, São Paulo, Brazil.

PY - 2012/11/28

Y1 - 2012/11/28

N2 - In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl) propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg 2+) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg 2+. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells.

AB - In this Letter we present a new probe, 2-amino-3-hydroxy-2-(hydroxymethyl) propyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (PMR), which can reversibly detect mercuric ions (Hg 2+) in HEPES buffer under physiological conditions. Possible interference with other analytes was examined. PMR displays a highly selective decrease of its fluorescence at 460 nm when it reacts with Hg 2+. Interestingly, the probe can also be used as a fluorescent turn-on sensor for biologically relevant thiols such as glutathione and cysteine. PMR can be used to determine mercury in living cells.

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ER -

A selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells

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