TY - JOUR
T1 - Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program
T2 - A Scoping Review
AU - for the ECHO Cohort Consortium
AU - Barrett, Emily S.
AU - Ames, Jennifer L.
AU - Eick, Stephanie M.
AU - Peterson, Alicia K.
AU - Rivera-Núñez, Zorimar
AU - Starling, Anne P.
AU - Buckley, Jessie P.
AU - Slaughter, Jonathan
AU - Schmidt, Rebecca
AU - Santos, Hudson
AU - Nguyen, Hong Ngoc
AU - Mumford, Sunni L.
AU - Hunt, Kelly J.
AU - Hedderson, Monique Marie
AU - Barrett, Emily S.
AU - Rivera-Spoljaric, Katherine
AU - Zhao, Qi
AU - Straughen, Jennifer
AU - Hartert, Tina
AU - Stroustrup, Annemarie
AU - Singh, Anne Marie
AU - Sathyanarayana, Sheela
AU - Wright, Rosalind
AU - Trasande, Leonardo
AU - Stanford, Joseph
AU - Schantz, Susan
AU - Herbstman, Julie
AU - Kerver, Jean
AU - O‟Shea, Mike
AU - Oken, Emily
AU - O‟Connor, Thomas
AU - Lyall, Kristen
AU - McEvoy, Cynthia
AU - Weiss, Scott
AU - MacKenzie, Debra
AU - Leve, Leslie
AU - Lester, Barry
AU - Karr, Catherine
AU - Karagas, Margaret
AU - Hipwell, Alison
AU - Hertz-Picciotto, Irva
AU - Breton, Carrie
AU - Gern, James
AU - Ferrara, Assiamira
AU - Elliott, Amy
AU - Dunlop, Anne
AU - Duarte, Cristiane
AU - Mitchell, Daphne Koinis
AU - Dabelea, Dana
AU - Camargo, Carlos
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Purpose of Review: Environmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early environmental exposures have been limited in size and diversity, hindering power and generalizability. With harmonized data from over 60,000 participants representing 69 pregnancy cohorts, the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) Program is the largest study of U.S. children’s health. Here, we: (1) review ECHO-wide studies of chemical exposures and maternal-child health; and (2) outline opportunities for future research using ECHO data. Recent Findings: As of early 2024, in addition to over 200 single-cohort (or award) papers on chemical exposures supported by ECHO, ten collaborative multi-cohort papers have been made possible by ECHO data harmonization and new data collection. Multi-cohort papers have examined prenatal exposure to per- and polyfluoroalkyl substances (PFAS), phthalates, phenols and parabens, organophosphate esters (OPEs), metals, melamine and aromatic amines, and emerging contaminants. They have primarily focused on describing patterns of maternal exposure or examining associations with maternal and infant outcomes; fewer studies have examined later child outcomes (e.g., autism) although follow up of enrolled ECHO children continues. The NICHD’s Data and Specimen Hub (DASH) database houses extensive ECHO data including over 470,000 chemical assay results and complementary data on priority outcome areas (pre, peri-, and postnatal, airway, obesity, neurodevelopment, and positive health), making it a rich resource for future analyses. Summary: ECHO’s extensive data repository, including biomarkers of chemical exposures, can be used to advance our understanding of environmental influences on children’s health. Although few published studies have capitalized on these unique harmonized data to date, many analyses are underway with data now widely available.
AB - Purpose of Review: Environmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early environmental exposures have been limited in size and diversity, hindering power and generalizability. With harmonized data from over 60,000 participants representing 69 pregnancy cohorts, the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) Program is the largest study of U.S. children’s health. Here, we: (1) review ECHO-wide studies of chemical exposures and maternal-child health; and (2) outline opportunities for future research using ECHO data. Recent Findings: As of early 2024, in addition to over 200 single-cohort (or award) papers on chemical exposures supported by ECHO, ten collaborative multi-cohort papers have been made possible by ECHO data harmonization and new data collection. Multi-cohort papers have examined prenatal exposure to per- and polyfluoroalkyl substances (PFAS), phthalates, phenols and parabens, organophosphate esters (OPEs), metals, melamine and aromatic amines, and emerging contaminants. They have primarily focused on describing patterns of maternal exposure or examining associations with maternal and infant outcomes; fewer studies have examined later child outcomes (e.g., autism) although follow up of enrolled ECHO children continues. The NICHD’s Data and Specimen Hub (DASH) database houses extensive ECHO data including over 470,000 chemical assay results and complementary data on priority outcome areas (pre, peri-, and postnatal, airway, obesity, neurodevelopment, and positive health), making it a rich resource for future analyses. Summary: ECHO’s extensive data repository, including biomarkers of chemical exposures, can be used to advance our understanding of environmental influences on children’s health. Although few published studies have capitalized on these unique harmonized data to date, many analyses are underway with data now widely available.
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U2 - 10.1007/s40572-024-00456-5
DO - 10.1007/s40572-024-00456-5
M3 - Review article
C2 - 38985433
AN - SCOPUS:85198502785
SN - 2196-5412
VL - 11
SP - 390
EP - 403
JO - Current Environmental Health Reports
JF - Current Environmental Health Reports
IS - 3
ER -