Matsushita, K., van der Velde, M., Astor, B. C., Woodward, M., Levey, A. S., de Jong, P. E., Coresh, J., Gansevoort, R. T., El-Nahas, M., Eckardt, K. U., Kasiske, B. L., Tonelli, M., Hemmelgarn, B., Wang, Y., Atkins, R. C., Polkinghorne, K. R., Chadban, S. J., Shankar, A., Klein, R., ... Manley, T. (2010). Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. The Lancet, 375(9731), 2073-2081. https://doi.org/10.1016/S0140-6736(10)60674-5
Matsushita, K, van der Velde, M, Astor, BC, Woodward, M, Levey, AS, de Jong, PE, Coresh, J, Gansevoort, RT, El-Nahas, M, Eckardt, KU, Kasiske, BL, Tonelli, M, Hemmelgarn, B, Wang, Y, Atkins, RC, Polkinghorne, KR, Chadban, SJ, Shankar, A, Klein, R, Klein, BEK, Wang, H, Wang, F, Zhang, L, Liu, L, Shlipak, M, Sarnak, MJ, Katz, R, Fried, LP, Jafar, T, Islam, M, Hatcher, J, Poulter, N, Chaturvedi, N, Rothenbacher, D, Brenner, H, Raum, E, Koenig, W, Fox, CS, Hwang, SJ, Meigs, JB, Cirillo, M, Hallan, S, Lydersen, S, Holmen, J, Shlipak, M, Sarnak, MJ, Katz, R, Fried, LP, Roderick, P, Nitsch, D, Fletcher, A, Bulpitt, C, Ohkubo, T, Metoki, H, Nakayama, M, Kikuya, M, Imai, Y, Jassal, SK, Barrett-Connor, E, Bergstrom, J, Warnock, DG, Muntner, P, Judd, S, McClellan, WM, Cushman, M, Howard, G, McClure, LA, Jee, SH, Kimm, H, Yun, JE, Wen, CP, Wen, SF, Tsao, CK, Tsai, MK, Ärnlöv, J, Auguste, P, Veldhuis, K, Camarata, L, Thomas, B & Manley, T 2010, 'Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis', The Lancet, vol. 375, n° 9731, pp. 2073-2081. https://doi.org/10.1016/S0140-6736(10)60674-5
@article{6be36d4505ea4b55ba217e07e26cabd3,
title = "Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis",
abstract = "Background: Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods: In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings: The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2, adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05-1·32) for eGFR 60 mL/min/1·73 m2, 1·57 (1·39-1·78) for 45 mL/min/1·73 m2, and 3·14 (2·39-4·13) for 15 mL/min/1·73 m2. ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15-1·26) for ACR 1·1 mg/mmol, 1·63 (1·50-1·77) for 3·4 mg/mmol, and 2·22 (1·97-2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation: eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding: Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.",
author = "Kunihiro Matsushita and {van der Velde}, Marije and Astor, {Brad C.} and Mark Woodward and Levey, {Andrew S.} and {de Jong}, {Paul E.} and Josef Coresh and Gansevoort, {Ron T.} and Meguid El-Nahas and Eckardt, {Kai Uwe} and Kasiske, {Bertram L.} and Marcello Tonelli and Brenda Hemmelgarn and Yaping Wang and Atkins, {Robert C.} and Polkinghorne, {Kevan R.} and Chadban, {Steven J.} and Anoop Shankar and Ronald Klein and Klein, {Barbara E.K.} and Haiyan Wang and Fang Wang and Luxia Zhang and Lisheng Liu and Michael Shlipak and Sarnak, {Mark J.} and Ronit Katz and Fried, {Linda P.} and Tazeen Jafar and Muhammad Islam and Juanita Hatcher and Neil Poulter and Nish Chaturvedi and Dietrich Rothenbacher and Hermann Brenner and Elke Raum and Wolfgang Koenig and Fox, {Caroline S.} and Hwang, {Shih Jen} and Meigs, {James B.} and Massimo Cirillo and Stein Hallan and Stian Lydersen and Jostein Holmen and Michael Shlipak and Sarnak, {Mark J.} and Ronit Katz and Fried, {Linda P.} and Paul Roderick and Dorothea Nitsch and Astrid Fletcher and Christopher Bulpitt and Takayoshi Ohkubo and Hirohito Metoki and Masaaki Nakayama and Masahiro Kikuya and Yutaka Imai and Jassal, {Simerjot Kaur} and Elizabeth Barrett-Connor and Jaclyn Bergstrom and Warnock, {David G.} and Paul Muntner and Suzanne Judd and McClellan, {William M.} and Mary Cushman and George Howard and McClure, {Leslie A.} and Jee, {Sun Ha} and Heejin Kimm and Yun, {Ji Eun} and Wen, {Chi Pang} and Wen, {Sung Feng} and Tsao, {Chwen Keng} and Tsai, {Min Kuang} and Johan {\"A}rnl{\"o}v and Priscilla Auguste and Kasper Veldhuis and Laura Camarata and Beverly Thomas and Tom Manley",
note = "Funding Information: The Chronic Kidney Disease Prognosis Consortium is supported by KDIGO and the US National Kidney Foundation. The meta-analyses undertaken jointly at Johns Hopkins School of Public Health, Baltimore, MD, USA, and University Medical Center Groningen, Groningen, Netherlands, were supported by the US National Kidney Foundation and the Dutch Kidney Foundation, respectively. KDIGO hosted the 2009 meeting of collaborators. ",
year = "2010",
doi = "10.1016/S0140-6736(10)60674-5",
language = "English",
volume = "375",
pages = "2073--2081",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9731",
}
TY - JOUR
T1 - Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts
T2 - a collaborative meta-analysis
AU - Matsushita, Kunihiro
AU - van der Velde, Marije
AU - Astor, Brad C.
AU - Woodward, Mark
AU - Levey, Andrew S.
AU - de Jong, Paul E.
AU - Coresh, Josef
AU - Gansevoort, Ron T.
AU - El-Nahas, Meguid
AU - Eckardt, Kai Uwe
AU - Kasiske, Bertram L.
AU - Tonelli, Marcello
AU - Hemmelgarn, Brenda
AU - Wang, Yaping
AU - Atkins, Robert C.
AU - Polkinghorne, Kevan R.
AU - Chadban, Steven J.
AU - Shankar, Anoop
AU - Klein, Ronald
AU - Klein, Barbara E.K.
AU - Wang, Haiyan
AU - Wang, Fang
AU - Zhang, Luxia
AU - Liu, Lisheng
AU - Shlipak, Michael
AU - Sarnak, Mark J.
AU - Katz, Ronit
AU - Fried, Linda P.
AU - Jafar, Tazeen
AU - Islam, Muhammad
AU - Hatcher, Juanita
AU - Poulter, Neil
AU - Chaturvedi, Nish
AU - Rothenbacher, Dietrich
AU - Brenner, Hermann
AU - Raum, Elke
AU - Koenig, Wolfgang
AU - Fox, Caroline S.
AU - Hwang, Shih Jen
AU - Meigs, James B.
AU - Cirillo, Massimo
AU - Hallan, Stein
AU - Lydersen, Stian
AU - Holmen, Jostein
AU - Shlipak, Michael
AU - Sarnak, Mark J.
AU - Katz, Ronit
AU - Fried, Linda P.
AU - Roderick, Paul
AU - Nitsch, Dorothea
AU - Fletcher, Astrid
AU - Bulpitt, Christopher
AU - Ohkubo, Takayoshi
AU - Metoki, Hirohito
AU - Nakayama, Masaaki
AU - Kikuya, Masahiro
AU - Imai, Yutaka
AU - Jassal, Simerjot Kaur
AU - Barrett-Connor, Elizabeth
AU - Bergstrom, Jaclyn
AU - Warnock, David G.
AU - Muntner, Paul
AU - Judd, Suzanne
AU - McClellan, William M.
AU - Cushman, Mary
AU - Howard, George
AU - McClure, Leslie A.
AU - Jee, Sun Ha
AU - Kimm, Heejin
AU - Yun, Ji Eun
AU - Wen, Chi Pang
AU - Wen, Sung Feng
AU - Tsao, Chwen Keng
AU - Tsai, Min Kuang
AU - Ärnlöv, Johan
AU - Auguste, Priscilla
AU - Veldhuis, Kasper
AU - Camarata, Laura
AU - Thomas, Beverly
AU - Manley, Tom
N1 - Funding Information:
The Chronic Kidney Disease Prognosis Consortium is supported by KDIGO and the US National Kidney Foundation. The meta-analyses undertaken jointly at Johns Hopkins School of Public Health, Baltimore, MD, USA, and University Medical Center Groningen, Groningen, Netherlands, were supported by the US National Kidney Foundation and the Dutch Kidney Foundation, respectively. KDIGO hosted the 2009 meeting of collaborators.
PY - 2010
Y1 - 2010
N2 - Background: Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods: In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings: The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2, adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05-1·32) for eGFR 60 mL/min/1·73 m2, 1·57 (1·39-1·78) for 45 mL/min/1·73 m2, and 3·14 (2·39-4·13) for 15 mL/min/1·73 m2. ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15-1·26) for ACR 1·1 mg/mmol, 1·63 (1·50-1·77) for 3·4 mg/mmol, and 2·22 (1·97-2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation: eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding: Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
AB - Background: Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods: In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings: The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2, adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05-1·32) for eGFR 60 mL/min/1·73 m2, 1·57 (1·39-1·78) for 45 mL/min/1·73 m2, and 3·14 (2·39-4·13) for 15 mL/min/1·73 m2. ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15-1·26) for ACR 1·1 mg/mmol, 1·63 (1·50-1·77) for 3·4 mg/mmol, and 2·22 (1·97-2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation: eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding: Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
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UR - http://www.scopus.com/inward/citedby.url?scp=77953291706&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(10)60674-5
DO - 10.1016/S0140-6736(10)60674-5
M3 - Article
C2 - 20483451
AN - SCOPUS:77953291706
SN - 0140-6736
VL - 375
SP - 2073
EP - 2081
JO - The Lancet
JF - The Lancet
IS - 9731
ER -