@article{fdd7697819d0468184fc2b7fd70d030e,
title = "Design and synthesis of a new coumarin-based 'turn-on' fluorescent probe selective for Cu +2 ",
abstract = "The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5- dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu +2, combined with a large fluorescence enhancement upon binding to Cu 2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu 2+ complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu +2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM.",
author = "Olimpo Garc{\'i}a-Beltr{\'a}n and Natalia Mena and Friedrich, {Leidi C.} and Netto-Ferreira, {Jos{\'e} Carlos} and V{\'i}ctor Vargas and Quina, {Frank H.} and N{\'u}{\~n}ez, {Marco T.} and Cassels, {Bruce K.}",
note = "Funding Information: This work was supported by the Millennium Scientific Initiative (Grant P05-001-F) and by the Instituto Nacional de Ci{\^e}ncia e Tecnologia do Meio Ambiente-USP (Brazil). JCNF thanks the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo (FAPESP) for a Visiting Professor Fellowship. FHQ and LCF acknowledge fellowship support from the CNPq-Brazil. ",
year = "2012",
month = sep,
day = "26",
doi = "10.1016/j.tetlet.2012.07.082",
language = "English",
volume = "53",
pages = "5280--5283",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "39",
}