IKK connects autophagy to major stress pathways

Alfredo Criollo; Laura Senovilla; Hélène Authier; Maria Chiara Maiuri; Eugenia Morselli; Ilio Vitale; Oliver Kepp; Ezgi Tasdemir; Lorenzo Galluzzi; Si Shen; Maximilien Tailler; Nicolas Delahaye; Antoine Tesniere; Daniela De Stefano; Aména Ben Younes; Francis Harper; Gérard Pierron; Sergio Lavandero; Laurence Zitvoge; Alain Israel; Véronique Baud; Guido Kroemer

doi:10.4161/auto.6.1.10818

IKK connects autophagy to major stress pathways

Alfredo Criollo, Laura Senovilla, Hélène Authier, Maria Chiara Maiuri, Eugenia Morselli, Ilio Vitale, Oliver Kepp, Ezgi Tasdemir, Lorenzo Galluzzi, Si Shen, Maximilien Tailler, Nicolas Delahaye, Antoine Tesniere, Daniela De Stefano, Aména Ben Younes, Francis Harper, Gérard Pierron, Sergio Lavandero, Laurence Zitvoge, Alain IsraelVéronique Baud, Guido Kroemer

Universidad de Chile

Résultat de recherche › examen par les pairs

39 Citations (Scopus)

Résumé

Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

Langue d'origine	English
Pages (de-à)	189-191
Nombre de pages	3
Journal	Autophagy
Volume	6
Numéro de publication	1
DOI	https://doi.org/10.4161/auto.6.1.10818
Statut de publication	Published - janv. 1 2010

Financement

G.K. is supported by the Ligue Nationale contre le Cancer, ANR, Cancéropôle Ile-de-France, Institut National du Cancer, European Commission (Active p53, Apo-Sys, RIGHT, ChemoRes, ApopTrain), and FRM. We thank the International Collaboration Program ECOS-CONICYT, grant C08S01 (to G.K. and S.L.). V.B. is supported by Agence Nationale pour la Recherche, Association pour la Recherche sur le Cancer, Belgian InterUniversity Attraction Pole, Cancéropole Ile-de-France, INCa and Université Paris Descartes.

Bailleurs de fonds	Numéro du bailleur de fonds
Belgian InterUniversity Attraction Pole, Cancéropole Ile-de-France
Cancéropôle Ile-de-France
ChemoRes
International Collaboration Program ECOS-CONICYT	C08S01
Association pour la Recherche sur le Cancer
European Commission
Agence Nationale de la Recherche
Fondation pour la Recherche Médicale
Ligue Contre le Cancer
Université Paris Descartes
Institut National Du Cancer
Right to Care

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

Accès au document

10.4161/auto.6.1.10818

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Criollo, A., Senovilla, L., Authier, H., Maiuri, M. C., Morselli, E., Vitale, I., Kepp, O., Tasdemir, E., Galluzzi, L., Shen, S., Tailler, M., Delahaye, N., Tesniere, A., De Stefano, D., Younes, A. B., Harper, F., Pierron, G., Lavandero, S., Zitvoge, L., ... Kroemer, G. (2010). IKK connects autophagy to major stress pathways. Autophagy, 6(1), 189-191. https://doi.org/10.4161/auto.6.1.10818

Criollo, A, Senovilla, L, Authier, H, Maiuri, MC, Morselli, E, Vitale, I, Kepp, O, Tasdemir, E, Galluzzi, L, Shen, S, Tailler, M, Delahaye, N, Tesniere, A, De Stefano, D, Younes, AB, Harper, F, Pierron, G, Lavandero, S, Zitvoge, L, Israel, A, Baud, V & Kroemer, G 2010, 'IKK connects autophagy to major stress pathways', Autophagy, vol. 6, n° 1, pp. 189-191. https://doi.org/10.4161/auto.6.1.10818

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abstract = "Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.",

author = "Alfredo Criollo and Laura Senovilla and H{\'e}l{\`e}ne Authier and Maiuri, {Maria Chiara} and Eugenia Morselli and Ilio Vitale and Oliver Kepp and Ezgi Tasdemir and Lorenzo Galluzzi and Si Shen and Maximilien Tailler and Nicolas Delahaye and Antoine Tesniere and {De Stefano}, Daniela and Younes, {Am{\'e}na Ben} and Francis Harper and G{\'e}rard Pierron and Sergio Lavandero and Laurence Zitvoge and Alain Israel and V{\'e}ronique Baud and Guido Kroemer",

note = "Funding Information: G.K. is supported by the Ligue Nationale contre le Cancer, ANR, Canc{\'e}rop{\^o}le Ile-de-France, Institut National du Cancer, European Commission (Active p53, Apo-Sys, RIGHT, ChemoRes, ApopTrain), and FRM. We thank the International Collaboration Program ECOS-CONICYT, grant C08S01 (to G.K. and S.L.). V.B. is supported by Agence Nationale pour la Recherche, Association pour la Recherche sur le Cancer, Belgian InterUniversity Attraction Pole, Canc{\'e}ropole Ile-de-France, INCa and Universit{\'e} Paris Descartes.",

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AU - Criollo, Alfredo

AU - Senovilla, Laura

AU - Authier, Hélène

AU - Maiuri, Maria Chiara

AU - Morselli, Eugenia

AU - Vitale, Ilio

AU - Kepp, Oliver

AU - Tasdemir, Ezgi

AU - Galluzzi, Lorenzo

AU - Shen, Si

AU - Tailler, Maximilien

AU - Delahaye, Nicolas

AU - Tesniere, Antoine

AU - De Stefano, Daniela

AU - Younes, Aména Ben

AU - Harper, Francis

AU - Pierron, Gérard

AU - Lavandero, Sergio

AU - Zitvoge, Laurence

AU - Israel, Alain

AU - Baud, Véronique

AU - Kroemer, Guido

N1 - Funding Information: G.K. is supported by the Ligue Nationale contre le Cancer, ANR, Cancéropôle Ile-de-France, Institut National du Cancer, European Commission (Active p53, Apo-Sys, RIGHT, ChemoRes, ApopTrain), and FRM. We thank the International Collaboration Program ECOS-CONICYT, grant C08S01 (to G.K. and S.L.). V.B. is supported by Agence Nationale pour la Recherche, Association pour la Recherche sur le Cancer, Belgian InterUniversity Attraction Pole, Cancéropole Ile-de-France, INCa and Université Paris Descartes.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

AB - Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

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IKK connects autophagy to major stress pathways

Résumé

Financement

ASJC Scopus Subject Areas

Accès au document

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