Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes

Program collaborators for Environmental influences on Child Health Outcomes (ECHO)

Résultat de rechercheexamen par les pairs

Résumé

Objectives: To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use. Study design: As part of the Environmental influences on Child Health Outcomes Program, we harmonized prenatal substance use data and child behavior outcomes from 2195 women and their 6- to 11-year-old children across 10 cohorts in the US and used latent class–adjusted regression models to predict parent-rated child behavior. Results: Three latent classes fit the data: low use (90.5%; n = 1986), primarily using no substances; licit use (6.6%; n = 145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n = 64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had greater levels of externalizing behavior than children exposed to low or no substances (P = .001, d = .64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (P < .001, d = .16). Conclusions: The differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multicohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.

Langue d'origineEnglish
Numéro d'article113468
JournalJournal of Pediatrics
Volume260
DOI
Statut de publicationPublished - sept. 2023

Financement

Bailleurs de fondsNuméro du bailleur de fonds
National Institutes of Health4UH3OD023282-03, 4UH3OD023365-03, 5UH3OD023348-05, UH3OD023349, U24OD023319, UH3OD023347, UH3OD023268, UH3OD023279, UH3OD023289, UG3OD023337, UH3OD 023286, U2COD023375, 4UH3OD023328-03, UH3 OD023285, 4UH3OD023271-03, 4UH3OD023244-03, 4UH3OD023248-03, 4UH3OD023342, 4UH3OD023275-03, U24OD023382, UH3 OD023389, R01 HD 034568, 5UH3OD023320-05
Office of the Director

    ASJC Scopus Subject Areas

    • Pediatrics, Perinatology, and Child Health

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    Citer

    Program collaborators for Environmental influences on Child Health Outcomes (ECHO) (2023). Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes. Journal of Pediatrics, 260, Article 113468. https://doi.org/10.1016/j.jpeds.2023.113468