TY - JOUR
T1 - Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
AU - Alcaino, Hernan
AU - Greig, Douglas
AU - Chiong, Mario
AU - Verdejo, Hugo
AU - Miranda, Rodrigo
AU - Concepcion, Roberto
AU - Vukasovic, José Luis
AU - Diaz-Araya, Guillermo
AU - Mellado, Rosemarie
AU - Garcia, Lorena
AU - Salas, Daniela
AU - Gonzalez, Leticia
AU - Godoy, Ivan
AU - Castro, Pablo
AU - Lavandero, Sergio
PY - 2008/7
Y1 - 2008/7
N2 - Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic heart failure patients (New York Heart Association functional class II-III, mean age 58 ± 10 years and mean left ventricular ejection fraction 25 ± 8%) and twelve age-and-sex-matched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3 ± 2.3 mg/dL vs. 6.1 ± 0.2 mg/dL, p < 0.05) and lower extracellular superoxide dismutase activity (136 ± 36 U ml- 1 min- 1 vs. 203 ± 61 U ml- 1 min- 1, p < 0.01) and endothelium-dependent vasodilatation (4.0 ± 1.6% v. 9.1 ± 3.0%, p < 0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity (r = 0.45; p < 0.01), and uric acid and endothelium-dependent vasodilatation (r = 0.35; p = 0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure.
AB - Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic heart failure patients (New York Heart Association functional class II-III, mean age 58 ± 10 years and mean left ventricular ejection fraction 25 ± 8%) and twelve age-and-sex-matched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3 ± 2.3 mg/dL vs. 6.1 ± 0.2 mg/dL, p < 0.05) and lower extracellular superoxide dismutase activity (136 ± 36 U ml- 1 min- 1 vs. 203 ± 61 U ml- 1 min- 1, p < 0.01) and endothelium-dependent vasodilatation (4.0 ± 1.6% v. 9.1 ± 3.0%, p < 0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity (r = 0.45; p < 0.01), and uric acid and endothelium-dependent vasodilatation (r = 0.35; p = 0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure.
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U2 - 10.1016/j.ejheart.2008.05.008
DO - 10.1016/j.ejheart.2008.05.008
M3 - Article
C2 - 18559296
AN - SCOPUS:46249107601
SN - 1388-9842
VL - 10
SP - 646
EP - 651
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
IS - 7
ER -
