Résumé
Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molinás population is of particular interest because in the last few decades it changed from being undernourished to suffering excess caloric intake, and it currently has the highest national rates of cardiovascular diseases, stomach cancer and gallbladder cancer. Between 2009 and 2011 Molinás poverty rate dropped from 24.1 % to 13.5 % (national average 20.4 %); in this period the county went from insufficient to almost complete basic sanitation. Despite these advances, chemical pollutants in the food and air are increasing. Thus, in Molina risk factors typical of both under-developed and developed countries coexist, generating a unique profile associated with inflammation, oxidative stress and chronic diseases. Methods/Design: MAUCO is the core project of the recently established Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile. In this study, we are enrolling and following 10,000 adults aged 38 to 74 years over 10 years. All eligible Molina residents will be enrolled. Participants were identified through a household census. Consenting individuals answer an epidemiological survey exploring risk factors (psycho-social, pesticides, diet, alcohol, and physical activity), medical history and physical and cognitive conditions; provide fasting blood, urine, and saliva samples; receive an electrocardiogram, abdominal ultrasound and bio-impedance test; and take a hand-grip strength test. These subjects will be re-interviewed after 2, 5 and 7 years. Active surveillance of health events is in place throughout the regional healthcare system. The MAUCO Bio-Bank will store 30 to 50 aliquots per subject using an NIH/NCI biorepository system for secure and anonymous linkage of samples with data. Discussion: MAUCÓs results will help design public health interventions tailored to agricultural populations in Latin America.
| Langue d'origine | English |
|---|---|
| Numéro d'article | 122 |
| Journal | BMC Public Health |
| Volume | 16 |
| Numéro de publication | 1 |
| DOI | |
| Statut de publication | Published - févr. 4 2016 |
Financement
MAUCO is the core project of the new Advanced Center for Chronic Diseases (ACCDiS), supported by the Fund for Research Centers in Priority Areas Program (FONDAP) of the Chilean National Commission for Scientific and Technological Research (CONICYT). MAUCO is initially funded for 10 years, and in this period MAUCO will recruit 10,000 adults from the general population and conduct follow-up visits. This work is funded by National Commission for Scientific & Technological Research (CONICYT) for the program Research Centers in Priority Areas (FONDAP) [grant number 15130011], and received material support from the Facultad Medicina, Universidad Católica del Maule and from the Ilustre Municipalidad de Molina (Molina County).
| Bailleurs de fonds | Numéro du bailleur de fonds |
|---|---|
| Chilean National Commission for Scientific and Technological Research | |
| Ilustre Municipalidad de Molina | |
| National Commission for Scientific & Technological Research | |
| Universidad Católica del Maule | |
| National Cancer Institute | ZIACP010218 |
| Comisión Nacional de Investigación Científica y Tecnológica | 15130011 |
ASJC Scopus Subject Areas
- Public Health, Environmental and Occupational Health
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
