The “sufficient cause” model framework applied to the periodontitis-systemic diseases link

Aderonke A. Akinkugbe, Panos N. Papapanou

Résultat de rechercheexamen par les pairs

4 Citations (Scopus)

Résumé

The premise for the oral-systemic diseases relationship dates to the early 20th century with the introduction of the focal infection theory that posited that oral disease affects overall health and wellbeing. While the biological plausibility for the link has been supported by experimental animal models and observational studies in humans, findings from interventional studies in which periodontal therapy failed to alleviate systemic health outcomes have often been interpreted as evidence against periodontitis contribution to the etiology of systemic health conditions. One concept of causation assumes a one-to-one correspondence between cause and effect. Nevertheless, common chronic diseases to which periodontitis is associated have multifactorial etiologies. This commentary provides an overview of Rothman's “sufficient cause” model as a framework for consideration of the oral-systemic diseases link.

Langue d'origineEnglish
Pages (de-à)343-347
Nombre de pages5
JournalJournal of Periodontology
Volume92
Numéro de publication3
DOI
Statut de publicationPublished - mars 2021

Financement

This work was partly supported by the National Institutes of Health/National Institute of Dental and Craniofacial Research (Grant No.: R03DE028403). The views expressed are solely the authors' views and do not represent the official views of the NIH/NIDCR. The authors declare no conflicts of interest with respect to the authorship and/or publication of this commentary. The authors thank Dr. Gerardo Heiss (W.R. Kenan Distinguished Professor of Epidemiology, University of North Carolina at Chapel Hill) for his comments on an earlier draft of this article. This work was partly supported by the National Institutes of Health/National Institute of Dental and Craniofacial Research (Grant No.: R03DE028403). The views expressed are solely the authors and does not represent the official views of the NIH/NIDCR. The authors declare no conflicts of interest with respect to the authorship and/or publication of this commentary. The authors thank Dr. Gerardo Heiss (W.R. Kenan Distinguished Professor of Epidemiology, University of North Carolina at Chapel Hill) for his comments on an earlier draft of this article.

Bailleurs de fondsNuméro du bailleur de fonds
National Institutes of Health
National Institute of Dental and Craniofacial ResearchR03DE028403
University of North Carolina Wilmington

    ASJC Scopus Subject Areas

    • Periodontics

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