TY - JOUR
T1 - Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery
AU - Haddow, James E.
AU - Cleary-Goldman, Jane
AU - McClain, Monica R.
AU - Palomaki, Glenn E.
AU - Neveux, Louis M.
AU - Lambert-Messerlian, Geralyn
AU - Canick, Jacob A.
AU - Malone, Fergal D.
AU - Porter, T. Flint
AU - Nyberg, David A.
AU - Bernstein, Peter S.
AU - D'Alton, Mary E.
PY - 2010/7
Y1 - 2010/7
N2 - Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.
AB - Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.
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U2 - 10.1097/AOG.0b013e3181e10b30
DO - 10.1097/AOG.0b013e3181e10b30
M3 - Article
C2 - 20567168
AN - SCOPUS:77954038273
SN - 0029-7844
VL - 116
SP - 58
EP - 62
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
IS - 1
ER -