Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery

James E. Haddow, Jane Cleary-Goldman, Monica R. McClain, Glenn E. Palomaki, Louis M. Neveux, Geralyn Lambert-Messerlian, Jacob A. Canick, Fergal D. Malone, T. Flint Porter, David A. Nyberg, Peter S. Bernstein, Mary E. D'Alton

Résultat de rechercheexamen par les pairs

61 Citations (Scopus)

Résumé

Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.

Langue d'origineEnglish
Pages (de-à)58-62
Nombre de pages5
JournalObstetrics and Gynecology
Volume116
Numéro de publication1
DOI
Statut de publicationPublished - juill. 2010

Financement

Bailleurs de fondsNuméro du bailleur de fonds
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentR01HD038652

    ASJC Scopus Subject Areas

    • Obstetrics and Gynaecology

    Empreinte numérique

    Plonger dans les sujets de recherche 'Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery'. Ensemble, ils forment une empreinte numérique unique.

    Citer