Tissue-specific endothelial cells: a promising approach for augmentation of soft tissue repair in orthopedics

Amir Lebaschi, Yusuke Nakagawa, Susumu Wada, Guang Ting Cong, Scott A. Rodeo

Résultat de rechercheexamen par les pairs

9 Citations (Scopus)

Résumé

Biologics are playing an increasingly significant role in the practice of modern medicine and surgery in general and orthopedics in particular. Cell-based approaches are among the most important and widely used modalities in orthopedic biologics, with mesenchymal stem cells and other multi/pluripotent cells undergoing evaluation in numerous preclinical and clinical studies. On the other hand, fully differentiated endothelial cells (ECs) have been found to perform critical roles in homeostasis of visceral tissues through production of an adaptive panel of so-called “angiocrine factors.” This newly discovered function of ECs renders them excellent candidates for novel approaches in cell-based biologics. Here, we present a review of the role of ECs and angiocrine factors in some visceral tissues, followed by an overview of current cell-based approaches and a discussion of the potential applications of ECs in soft tissue repair.

Langue d'origineEnglish
Pages (de-à)44-56
Nombre de pages13
JournalAnnals of the New York Academy of Sciences
Volume1410
Numéro de publication1
DOI
Statut de publicationPublished - 2017

Financement

The authors acknowledge with thanks the important data provided by Daniel J. Nolan, Ph.D.

Bailleurs de fondsNuméro du bailleur de fonds
National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin DiseasesT32AR007281

    ASJC Scopus Subject Areas

    • General Neuroscience
    • General Biochemistry,Genetics and Molecular Biology
    • History and Philosophy of Science

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