Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018

for the Central Africa IeDEA Consortium

doi:10.1002/jia2.25672

Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018

for the Central Africa IeDEA Consortium

Mailman School of Public Health

Résultat de recherche › examen par les pairs

6 Citations (Scopus)

Résumé

Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) is an open observational cohort study investigating impact, progression and long-term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA-IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cell count, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA-IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cell count at enrolment from 190 cells/µL in 2004 to 334 cells/µL in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/µL, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA-IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites.

Langue d'origine	English
Numéro d'article	e25672
Journal	Journal of the International AIDS Society
Volume	24
Numéro de publication	6
DOI	https://doi.org/10.1002/jia2.25672
Statut de publication	Published - juin 2021

Financement

The research reported in this publication was supported by the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID), the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), the National Heart, Lung and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Fogarty International Center (FIC), the National Library of Medicine (NLM) and the Office of the Director (OD) under Award Number U01AI096299 (Central Africa-IeDEA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Site investigators and cohorts Nimbona Pélagie, Association Nationale de Soutien aux Séropositifs et Malade du Sida (ANSS), Burundi; Patrick Gateretse, Jeanine Munezero, Valentin Nitereka, Théodore Niyongabo, Christelle Twizere, Centre National de Reference en Matière de VIH/SIDA, Burundi; Hélène Bukuru, Thierry Nahimana, Centre Hospitalo-Universitaire de Kamenge (CHUK), Burundi; Elysée Baransaka, Patrice Barasukana, Eugene Kabanda, Martin Manirakiza, François Ndikumwenayo, CHUK/Burundi National University, Burundi; Jérémie Biziragusenyuka, Ange Marie Michelline Munezero, Hospital Prince Régent Charles (HPRC), Burundi; Tabeyang Mbuh, Kinge Thompson Njie, Edmond Tchassem, Kien-Atsu Tsi, Bamenda Hospital, Cameroon; Rogers Ajeh, Mark Benwi, Marc Lionel Ngamani, Victorine Nkome, Falone Sandjong, Clinical Research Education and Consultancy (CRENC), Cameroon; Anastase Dzudie, CRENC and Douala General Hospital, Cameroon; Akindeh Mbuh, CRENC and University of Yaoundé, Cameroon; Djenabou Amadou, Amadou Dodo Balkissou, Eric Ngassam, Eric Walter Pefura Yone, Jamot Hospital, Cameroon; Alice Ndelle Ewanoge, Norbert Fuhngwa, Ernestine Kendowo, Chris Moki, Denis Nsame Nforniwe, Limbe Regional Hospital, Cameroon; Catherine Akele, Faustin Kitetele, Patricia Lelo, Martine Tabala, Kalembelembe Pediatric Hospital, Democratic Republic of Congo; Emile Wemakoy Okitolonda, Cherubin Ekembe, Kinshasa School of Public Health, Democratic Republic of Congo; Merlin Diafouka, Martin Herbas Ekat, Dominique Mahambou Nsonde, CTA Brazzaville, Republic of Congo; Adolphe Mafou, CTA Pointe-Noire, Republic of Congo; Nicole Ayinkamiye, Jules Igirimbabazi, Bethsaida Health Center, Rwanda; Emmanuel Ndamijimana, Providance Uwineza, Busanza Health Center, Rwanda; Emmanuel Habarurema, Marie Luise Nyiraneza, Gahanga Health Center, Rwanda; Dorothee Mukamusana, Liliane Tuyisenge, Gikondo Health Center, Rwanda; Catherine Kankindi, Christian Shyaka, Kabuga Health Center, Rwanda; Marie Grace Ingabire, Bonheur Uwakijijwe, Kicukiro Health Center, Rwanda; Jules Ndumuhire, Marie Goretti Nyirabahutu, Masaka Health Center, Rwanda; Yvette Ndoli, Oliver Uwamahoro, Nyarugunga Health Center, Rwanda; Ribakare Muhayimpundu, Sabin Nsanzimana, Eric Remera, Esperance Umumararungu, Rwanda Biomedical Center, Rwanda; Lydia Busingye, Alex M Butera, Josephine Gasana, Thierry Habiryayo, Charles Ingabire, Jules Kabahizi, Jean Chrysostome Kagimbana, Faustin Kanyabwisha, Gallican Kubwimana, Benjamin Muhoza, Athanase Munyaneza, Gad Murenzi, Francoise Musabyimana, Francine Mwiza, Gallican Nshogoza Rwibasira, Jean d'Amour Sinayobye, Patrick Tuyisenge, Rwanda Military Hospital, Rwanda; Chantal Benekigeri, Jacqueline Musaninyange, WE-ACTx Health Center, Rwanda. Coordinating and Data Centres Adebola Adedimeji, Kathryn Anastos, Madeline Dilorenzo, Lynn Murchison, Jonathan Ross, Marcel Yotebieng, Albert Einstein College of Medicine, USA; Diane Addison, Ellen Brazier, Heidi Jones, Elizabeth Kelvin, Sarah Kulkarni, Denis Nash, Matthew Romo, Olga Tymejczyk, Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), USA; Batya Elul, Columbia University, USA; Xiatao Cai, Allan Dong, Don Hoover, Hae-Young Kim, Chunshan Li, Qiuhu Shi, Data Solutions, USA; Robert Agler, Kathryn Lancaster, The Ohio State University, USA; Mark Kuniholm, University at Albany, State University of New York, USA; Andrew Edmonds, Angela Parcesepe, Jess Edwards, University of North Carolina at Chapel Hill, USA; Olivia Keiser, University of Geneva; Stephany Duda; Vanderbilt University School of Medicine, USA; April Kimmel, Virginia Commonwealth University School of Medicine, USA. The research reported in this publication was supported by the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID), the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), the National Heart, Lung and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Fogarty International Center (FIC), the National Library of Medicine (NLM) and the Office of the Director (OD) under Award Number U01AI096299 (Central Africa-IeDEA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research reported in this publication was supported by the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Child Health & Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), the National Heart, Lung and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Fogarty International Center (FIC), the National Library of Medicine (NLM) and the Office of the Director (OD) under Award Number U01AI096299 (Central Africa‐IeDEA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Eunice Kennedy Shriver

Bailleurs de fonds	Numéro du bailleur de fonds
ANSS
April Kimmel
Association Nationale de Soutien aux Séropositifs et Malade du Sida
Busanza Health Center
Centre Hospitalo-Universitaire de Kamenge
Clinical Research Education and Consultancy
Douala General Hospital
Esperance Umumararungu
Falone Sandjong
Kabuga Health Center
Nyarugunga Health Center
Public Health and Health Policy
University of Yaoundé
Victorine Nkome
WE-ACTx Health Center
National Institutes of Health
National Institute on Drug Abuse
National Institute on Alcohol Abuse and Alcoholism
National Heart, Lung, and Blood Institute
NIH Office of the Director
National Cancer Institute
National Institute of Allergy and Infectious Diseases	U01AI096299
Fogarty International Center
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Child Health and Human Development
U.S. National Library of Medicine
Office of the Director
City University of New York
School of Medicine, Vanderbilt University
Ohio State University
State University of New York
University of North Carolina at Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development
School of Medicine, Virginia Commonwealth University
Université de Genève
Rwanda Biomedical Centre

ASJC Scopus Subject Areas

Public Health, Environmental and Occupational Health
Infectious Diseases

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1002/jia2.25672

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for the Central Africa IeDEA Consortium (2021). Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018. Journal of the International AIDS Society, 24(6), Article e25672. https://doi.org/10.1002/jia2.25672

Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018. / for the Central Africa IeDEA Consortium.
Dans: Journal of the International AIDS Society, Vol. 24, N° 6, e25672, 06.2021.

Résultat de recherche › examen par les pairs

for the Central Africa IeDEA Consortium 2021, 'Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018', Journal of the International AIDS Society, vol. 24, n° 6, e25672. https://doi.org/10.1002/jia2.25672

@article{8749bdeeb8c3414bbdf53a8064d3764c,

title = "Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018",

abstract = "Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) is an open observational cohort study investigating impact, progression and long-term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA-IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cell count, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA-IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cell count at enrolment from 190 cells/µL in 2004 to 334 cells/µL in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/µL, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA-IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites.",

author = "{for the Central Africa IeDEA Consortium} and Adedimeji, {Adebola A.} and Hoover, {Donald R.} and Qiuhu Shi and Kim, {Hae Young} and Ellen Brazier and Jonathan Ross and Gad Murenzi and Christella Twizere and Patricia Lelo and Dominique Nsonde and Rogers Ajeh and Anastase Dzudie and Denis Nash and Marcel Yotebieng and Kathryn Anastos and Nimbona P{\'e}lagie and Patrick Gateretse and Jeanine Munezero and Valentin Nitereka and Th{\'e}odore Niyongabo and Christelle Twizere and H{\'e}l{\`e}ne Bukuru and Thierry Nahimana and Elys{\'e}e Baransaka and Patrice Barasukana and Eugene Kabanda and Martin Manirakiza and Fran{\c c}ois Ndikumwenayo and J{\'e}r{\'e}mie Biziragusenyuka and Munezero, {Ange Marie Michelline} and Tabeyang Mbuh and Njie, {Kinge Thompson} and Edmond Tchassem and Tsi, {Kien Atsu} and Mark Benwi and Ngamani, {Marc Lionel} and Victorine Nkome and Falone Sandjong and Akindeh Mbuh and Djenabou Amadou and Balkissou, {Amadou Dodo} and Eric Ngassam and Yone, {Eric Walter Pefura} and Ewanoge, {Alice Ndelle} and Norbert Fuhngwa and Ernestine Kendowo and Chris Moki and Nforniwe, {Denis Nsame} and Catherine Akele and Batya Elul",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.",

year = "2021",

month = jun,

doi = "10.1002/jia2.25672",

language = "English",

volume = "24",

journal = "Journal of the International AIDS Society",

issn = "1758-2652",

publisher = "International AIDS Society",

number = "6",

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TY - JOUR

T1 - Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) 2004 to 2018

AU - for the Central Africa IeDEA Consortium

AU - Adedimeji, Adebola A.

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Kim, Hae Young

AU - Brazier, Ellen

AU - Ross, Jonathan

AU - Murenzi, Gad

AU - Twizere, Christella

AU - Lelo, Patricia

AU - Nsonde, Dominique

AU - Ajeh, Rogers

AU - Dzudie, Anastase

AU - Nash, Denis

AU - Yotebieng, Marcel

AU - Anastos, Kathryn

AU - Pélagie, Nimbona

AU - Gateretse, Patrick

AU - Munezero, Jeanine

AU - Nitereka, Valentin

AU - Niyongabo, Théodore

AU - Twizere, Christelle

AU - Bukuru, Hélène

AU - Nahimana, Thierry

AU - Baransaka, Elysée

AU - Barasukana, Patrice

AU - Kabanda, Eugene

AU - Manirakiza, Martin

AU - Ndikumwenayo, François

AU - Biziragusenyuka, Jérémie

AU - Munezero, Ange Marie Michelline

AU - Mbuh, Tabeyang

AU - Njie, Kinge Thompson

AU - Tchassem, Edmond

AU - Tsi, Kien Atsu

AU - Benwi, Mark

AU - Ngamani, Marc Lionel

AU - Nkome, Victorine

AU - Sandjong, Falone

AU - Mbuh, Akindeh

AU - Amadou, Djenabou

AU - Balkissou, Amadou Dodo

AU - Ngassam, Eric

AU - Yone, Eric Walter Pefura

AU - Ewanoge, Alice Ndelle

AU - Fuhngwa, Norbert

AU - Kendowo, Ernestine

AU - Moki, Chris

AU - Nforniwe, Denis Nsame

AU - Akele, Catherine

AU - Elul, Batya

PY - 2021/6

Y1 - 2021/6

N2 - Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) is an open observational cohort study investigating impact, progression and long-term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA-IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cell count, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA-IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cell count at enrolment from 190 cells/µL in 2004 to 334 cells/µL in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/µL, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA-IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites.

AB - Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA-IeDEA) is an open observational cohort study investigating impact, progression and long-term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA-IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cell count, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA-IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cell count at enrolment from 190 cells/µL in 2004 to 334 cells/µL in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/µL, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA-IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites.

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