Karen S. Marder

2025

Mini-mental status examination phenotyping for Alzheimer’s disease patients using both structured and narrative electronic health record features

Idnay, B., Zhang, G., Chen, F., Ta, C. N., Schelke, M. W., Marder, K. & Weng, C., Jan 1 2025, In: Journal of the American Medical Informatics Association : JAMIA. 32, 1, p. 119-128 10 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Spiritual Well-Being and Phenoconversion in Huntington’s Disease: Analysis from the Prospective Huntington at Risk Observational Study

on behalf of the PHAROS Investigators of the Huntington Study Group, 2025, (Accepted/In press) In: Journal of Palliative Medicine.

Research output: Contribution to journal › Article › peer-review

What research participants say about their research experiences in Empowering the Participant Voice: Outcomes and actionable data

Kost, R. G., Andrews, J., Chatterjee, R., Cheng, A. C., Connally, L., Dozier, A., Dykes, C., Ford, D., Green, N. S., Jiang, C., Khoury-Shakour, S., Lindo, S., Marder, K., Martinez, L., Qureshi, A., Roberts, J. & Schlesinger, N., Jan 10 2025, In: Journal of Clinical and Translational Science. 9, 1, e43.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

What Research Participants Say about Their Research Experiences in Empowering the Participant Voice: Outcomes and Actionable Data

Kost, R. G., Andrews, J., Chatterjee, R., Cheng, A. C., Connally, L., Dozier, A., Dykes, C., Ford, D., Green, N. S., Jiang, C., Khoury-Shakour, S., Lindo, S., Marder, K., Martinez, L., Qureshi, A., Roberts, J. & Schlesinger, N., 2025, (Accepted/In press) In: Journal of Clinical and Translational Science.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Association of CSF α-Synuclein Seeding Amplification Assay Results with Clinical Features of Possible and Probable Dementia with Lewy Bodies

Coughlin, D. G., Macleod, K. R., Middleton, J. S., Bozoki, A. C., Galvin, J. E., Irwin, D. J., Lippa, C. F., Litvan, I., Lopez, O. L., Berman, S., Tsuang, D. W., Zabetian, C. P., Honig, L. S., Marder, K. S., Fleisher, J. E., Sabbagh, M., Wint, D., Taylor, A. S., Bekris, L. & Leverenz, J. B. & 1 others, Galasko, D., Jul 11 2024, In: Neurology. 103, 3, e209656.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Clinical Manifestations

Rizer, S., Joyce, J. L., Dargie, S. A., Chapman, S., Libon, D. J., Mora, L., Tom, S. E., Marder, K., Rosser, M. & Cosentino, S., Dec 1 2024, In: Alzheimer's and Dementia. 20, p. e092636

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical Manifestations

Joyce, J. L., Cosentino, S., Rizer, S., Dargie, S. A., Chapman, S., Mora, L., Libon, D. J., Tom, S. E., Marder, K. & Rosser, M., Dec 1 2024, In: Alzheimer's and Dementia. 20, p. e092824

Research output: Contribution to journal › Article › peer-review

Open Access

Confronting Alzheimer’s Disease Risk in Women: A Feasibility Study of Memory Screening as Part of the Annual Gynecological Well-Woman Visit

Joyce, J. L., Chapman, S., Waltrip, L., Caes, D., Gottesman, R., Rizer, S., Haque, H., Golfer, L., Mayeux, R. P., D’Alton, M. E., Marder, K., Rosser, M. & Cosentino, S., Sept 1 2024, In: Journal of Women's Health. 33, 9, p. 1211-1218 8 p.

Research output: Contribution to journal › Article › peer-review

Dynamic undirected graphical models for time-varying clinical symptom and neuroimaging networks

McDonnell, E. I., Xie, S., Marder, K., Cui, F. & Wang, Y., Sept 20 2024, In: Statistics in Medicine. 43, 21, p. 4131-4147 17 p.

Research output: Contribution to journal › Article › peer-review

Participant-reported personal utility of genetic testing for Parkinson’s disease and interest in clinical trial participation

Oas, H., Cook, L., Schwantes-An, T. H., Walsh, L. E., Wills, A. M., Mata, I. F., Nance, M. A., Beck, J. C., Naito, A., Marder, K., Alcalay, R. N. & Verbrugge, J., Dec 2024, In: npj Parkinson's Disease. 10, 1, 202.

Research output: Contribution to journal › Article › peer-review

Open Access

Promoting equity in clinical research: The role of social determinants of health

Idnay, B., Fang, Y., Stanley, E., Ruotolo, B., Chung, W. K., Marder, K. & Weng, C., Aug 2024, In: Journal of Biomedical Informatics. 156, 104663.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study

LEGATO-HD Study Group, Mar 2024, In: The Lancet Neurology. 23, 3, p. 243-255 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Sociotechnical feasibility of natural language processing-driven tools in clinical trial eligibility prescreening for Alzheimer’s disease and related dementias

Idnay, B., Liu, J., Fang, Y., Hernandez, A., Kaw, S., Etwaru, A., Padilla, J. J., Ramírez, S. O., Marder, K., Weng, C. & Schnall, R., May 1 2024, In: Journal of the American Medical Informatics Association : JAMIA. 31, 5, p. 1062-1073 12 p.

Research output: Contribution to journal › Article › peer-review

2023

Developing Topics

Sudhakar, T. D., Levendovszky, S. R., Zabetian, C. P., Tsuang, D. W., Pillai, J. A., Rao, S. M., Oguh, O., Lippa, C., Lopez, O. L., Berman, S., Irwin, D. J., Galasko, D. R., Litvan, I., Marder, K., Honig, L. S., Fleisher, J. E., Galvin, J. E., Bozoki, A., Taylor, A. & Sabbagh, M. & 4 others, Wint, D., Cholerton, B., Leverenz, J. B. & Olson, V., Dec 1 2023, In: Alzheimer's and Dementia. 19, p. e082764

Research output: Contribution to journal › Article › peer-review

Open Access

Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort

the MJFF Global Genetic Parkinson's Disease Study Group, Feb 1 2023, In: Movement Disorders. 38, 2, p. 286-303 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Citations (Scopus)

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Anastasi, J. K., Capili, B., Norton, M., McMahon, D. J. & Marder, K., 2023, In: Frontiers in Pain Research. 4, 1330937.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Citations (Scopus)

2022

Longitudinal Measurements of Glucocerebrosidase activity in Parkinson’s patients

The Parkinson’s Progression Markers Initiative, Oct 2022, In: Annals of Clinical and Translational Neurology. 7, 10, p. 1816-1830 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

2020

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

PPMI Investigators, Jan 2020, In: The Lancet Neurology. 19, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Citations (Scopus)

Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson's Disease Penetrance

the Michael J. Fox Foundation LRRK2 Cohort Consortium, Oct 1 2020, In: Movement Disorders. 35, 10, p. 1755-1764 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Citations (Scopus)

2019

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study

European Huntington's Disease Network & Huntington Study Group investigators, Feb 2019, In: The Lancet Neurology. 18, 2, p. 165-176 12 p.

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Using global team science to identify genetic parkinson's disease worldwide

MJFF Global Genetic Parkinson's Disease Study Group, Aug 2019, In: Annals of Neurology. 86, 2, p. 153-157 5 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

26 Citations (Scopus)

2018

LRP10 in α-synucleinopathies

International DLB Genetics Consortium, Dec 2018, In: The Lancet Neurology. 17, 12, p. 1032-1033 2 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

10 Citations (Scopus)

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

the Parkinson's Progression Markers Initiative, Dec 2018, In: Annals of Clinical and Translational Neurology. 5, 12, p. 1460-1477 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

356 Citations (Scopus)

2014

Tracking motor impairments in the progression of Huntington's disease

Long, J. D., Paulsen, J. S., Marder, K., Zhang, Y., Kim, J. I., Mills, J. A., Cross, S., Ryan, P., Epping, E. A., Vik, S., Chiu, E., Preston, J., Goh, A., Antonopoulos, S., Loi, S., Chua, P., Komiti, A., Raymond, L., Decolongon, J. & Fan, M. & 78 others, Coleman, A., Ross, C. A., Varvaris, M., Yoritomo, N., Mallonee, W. M., Suter, G., Samii, A., Macaraeg, A., Jones, R., Wood-Siverio, C., Factor, S. A., Barker, R. A., Mason, S., Guzman, N. V., McCusker, E., Griffith, J., Loy, C., Gunn, D., Orth, M., Sübmuth, S., Barth, K., Trautmann, S., Schwenk, D., Eschenbach, C., Quaid, K., Wesson, M., Wojcieszek, J., Guttman, M., Sheinberg, A., Law, A., Perlman, S., Clemente, B., Geschwind, M. D., Sha, S., Satris, G., Warner, T., Burrows, M., Rosser, A., Price, K., Hunt, S., Marshall, F., Chesire, A., Wodarski, M., Hickey, C., Panegyres, P., Lee, J., Tedesco, M., Maxwell, B., Perlmutter, J., Barton, S., Smith, S., Miedzybrodzka, Z., Rae, D., D'Alessandro, M., Craufurd, D., Bek, J., Howard, E., Mazzoni, P., Marder, K., Wasserman, P., Kumar, R., Erickson, D., Nickels, B., Wheelock, V., Kjer, L., Martin, A., Farias, S., Martin, W., King, P., Wieler, M., Sran, S., Suchowersky, O., Ahmed, A., Rao, S., Reece, C., Bura, A., Mourany, L. & Pallai, J., Mar 2014, In: Movement Disorders. 29, 3, p. 311-319 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Citations (Scopus)

2013

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

MacLeod, D. A., Rhinn, H., Kuwahara, T., Zolin, A., Di Paolo, G., McCabe, B. D., Marder, K. S., Honig, L. S., Clark, L. N., Small, S. A. & Abeliovich, A., 2013, In: Neuron. 77, 5, p. 994 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

19 Citations (Scopus)

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk

MacLeod, D. A., Rhinn, H., Kuwahara, T., Zolin, A., DiPaolo, G., McCabe, B. D., Marder, K. S., Honig, L. S., Clark, L. N., Small, S. A. & Abeliovich, A., Jul 10 2013, In: Neuron. 79, 1, p. 202-203 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

3 Citations (Scopus)

2012

Cognitive performance of GBA mutation carriers with early-onset PD The CORE-PD study

Alcalay, R. N., Caccappolo, E., Mejia-Santana, H., Tang, M. X., Rosado, L., Reilly, M. O., Ruiz, D., Ross, B., Verbitsky, M., Kisselev, S., Louis, E., Comella, C., Colcher, A., Jennings, D., Nance, M., Bressman, S., Scott, W. K., Tanner, C., Mickel, S. & Andrews, H. & 18 others, Waters, C., Fahn, S., Cote, L., Frucht, S., Ford, B., Rezak, M., Novak, K., Friedman, J. H., Pfeiffer, R., Marsh, L., Hiner, B., Siderowf, A., Payami, H., Molho, E., Factor, S., Ottman, R., Clark, L. N. & Marder, K., May 1 2012, In: Neurology. 78, 18, p. 1434-1440 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

226 Citations (Scopus)

Population stratiWcation may bias analysis of PGC-1α as a modiWer of age at Huntington disease motor onset

Ramos, E. M., Latourelle, J. C., Lee, J. H., Gillis, T., Mysore, J. S., Squitieri, F., Di Pardo, A., Di Donato, S., Hayden, M. R., Morrison, P. J., Nance, M., Ross, C. A., Margolis, R. L., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R. J., McCusker, E., Novelletto, A. & Frontali, M. & 16 others, Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M. H., Hersch, S. M., Rosas, H. D., Lucente, D., Harrison, M. B., Zanko, A., Marder, K., Gusella, J. F., Lee, J. M., Alonso, I., Sequeiros, J., Myers, R. H. & MacDonald, M. E., Dec 2012, In: Human Genetics. 131, 12, p. 1833-1840 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

2010

Preface

Fahn, S., Marder, K. & Côé, L., 2010, In: Movement Disorders. 25, SUPPL. 1, p. S1

Research output: Contribution to journal › Editorial › peer-review

2006

Donepezil in patients with severe Alzheimer's disease: double-blind parallel-group, placebo controlled study.

Marder, K., Sept 2006, In: Current Neurology and Neuroscience Reports. 6, 5, p. 364-363 2 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2005

A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington's disease

Chatterjee, A., Anderson, K. E., Moskowitz, C. B., Hauser, W. A. & Marder, K. S., 2005, In: Journal of Neuropsychiatry and Clinical Neurosciences. 17, 3, p. 378-383 6 p.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Vitamin E and donepezil for the treatment of mild cognitive impairment.

Marder, K., 2005, In: Current Neurology and Neuroscience Reports. 5, 5, p. 337-338 2 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2004

Memantine approved to treat moderate to severe Alzheimer’s disease

Marder, K., Oct 1 2004, In: Current Neurology and Neuroscience Reports. 4, 5, p. 349-350 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

11 Citations (Scopus)

2003

Erratum: Familial aggregation of early- and late-onset Parkinson's disease (Annals of Neurology (2003) 54 (507-513))

Marder, K., Levy, G., Louis, E. D., Mejia-Santana, H., Cote, L., Andrews, H., Harris, J., Waters, C., Ford, B., Frucht, S., Fahn, S. & Ottman, R., Nov 2003, In: Annals of Neurology. 54, 5, p. 693 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Vaccine trial in Alzheimer's disease is halted.

Marder, K., 2003, In: Current Neurology and Neuroscience Reports. 3, 5, p. 371-372 2 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2002

Donepezil for cognitive impairment in Parkinson's disease: a randomized controlled trial.

Marder, K., 2002, In: Current Neurology and Neuroscience Reports. 2, 5, p. 390-391 2 p.

Research output: Contribution to journal › Editorial › peer-review

3 Citations (Scopus)

Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomized trial.

Marder, K., 2002, In: Current Neurology and Neuroscience Reports. 2, 5, p. 389-390 2 p.

Research output: Contribution to journal › Editorial › peer-review

4 Citations (Scopus)

The parkin gene is not involved in late-onset Parkinson's disease [1] (multiple letters)

Kann, M., Hedrich, K., Vieregge, P., Jacobs, H., Müller, B., Kock, N., Schwinger, E., Klein, C., Marder, K., Harris, J., Meija-Santana, H., Bressman, S., Ozelius, L. J., Lang, A. E. & Pramstaller, P. P., Mar 12 2002, In: Neurology. 58, 5, p. 835 1 p.

Research output: Contribution to journal › Letter › peer-review

6 Citations (Scopus)

2001

Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex. 1994.

Lynch, T., Sano, M., Marder, K. S., Bell, K. L., Foster, N. L., Defendini, R. F., Sima, A. A., Keohane, C., Nygaard, T. G., Fahn, S., Mayeux, R., Rowland, L. P. & Wilhelmsen, K. C., Nov 2001, In: Neurology. 57, 10 Suppl 3, p. S39-45

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Cognitive correlates of obsessive and compulsive symptoms in Huntington's disease

Anderson, K. E., Louis, E. D., Stern, Y. & Marder, K. S., May 2001, In: American Journal of Psychiatry. 158, 5, p. 799-801 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Citations (Scopus)

1999

Arm elevation in Huntington's disease: Dystonia or levitation?

Louis, E. D., Marder, K., Moskowitz, C. & Greene, P., 1999, In: Movement Disorders. 14, 6, p. 1035-1038 4 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Neurological outcomes in late HIV infection: Adverse impact of neurological impairment on survival and protective effect of antiviral therapy

Price, R. W., Yiannoutsos, C. T., Clifford, D. B., Zaborski, L., Tselis, A., Sidtis, J. J., Cohen, B., Hall, C. D., Erice, A., Henry, K., Glicksman, M., Powderly, W. G., Swindells, S., Rudberg, G., Cooper, C., Kessler, H., Borucki, M., Galatas, P., Van der Horst, C. & Kapoor, C. & 79 others, Robertson, K., Robertson, W., Simpson, D., Dorfman, D., Sinclair, B., Olson, C., Marder, K., Crawford, M., Flynn, T., Wanke, C., Craven, D., Reid, J., Holloway, R., Fife, K., Todd, K., Marra, C. M., Collier, A. C., Cummings, D., Tyler, K. L., Putnam, B. A., Hollander, H., Walker, J., Matozzo, I., Frank, I., Kumar, P., Guerrero, M., Kruger, S., Fischl, M., Scerpella, E., Rodriguez, A., Frame, P. T., Kohrs, S., Lederman, M., Vazquez, G., Lopez, I., Delapenha, R., Butler, Y., Saag, M., Squires, K. E., Deloach, S., McCulloch, B., Cooney, E., Frank, C., Nealon, M. J., Ponticello, L., Sociro, R., Valentine, F., Vogler, M., Chirgwin, K., Szebenyi, S., Rinki, M., Slamowitz, D., Ogata-Arakaki, D., Millard, M., Ellis, R., Snyder, R., Eyster, M. E., Ehmann, C., Kessler, C., Quinlan, C., Brettler, D. B., Forand, P., Seremetis, S., Brady, M., Hunkler, J., Saba, H., Tannenbaum, B., Hoots, K., Coates, T. D., Sosa, A., South, M. A., Rubinstein, A., Weiler-Einstein, J., Gill, J., Timmons, P., Stabler, S., Giambartolomei, S., Clax, P. & Kenton, A., 1999, In: AIDS. 13, 13, p. 1677-1685 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

124 Citations (Scopus)

1998

A radomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease

Devanand, D. P., Marder, K., Michaels, K. S., Sackeim, H. A., Bell, K., Sullivan, M. A., Cooper, T. B., Pelton, G. H. & Mayeux, R., Nov 1998, In: American Journal of Psychiatry. 155, 11, p. 1512-1520 9 p.

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia

Stern, Y., Tang, M. X., Jacobs, D. M., Sano, M., Marder, K., Bell, K., Dooneief, G., Schofield, P. & Côté, L., May 1998, In: Journal of the International Neuropsychological Society. 4, 3, p. 279-284 6 p.

Research output: Contribution to journal › Article › peer-review