Project Details
Description
Work on artificial enzymes will be pursued. This includes compounds
combining cyclodextrins, pyridoxal or pyridoxamine with binding groups,
such as cyclodextrins, macrocycles, or steroids; appropriate placement of
basic catalytic groups will also be used to promote specific processes.
The characteristic specificities of enzyme reactions--for substrate, for
chemical reaction, for region of the substrate, and for stereochemistry of
substrate and produce--will be mimicked. Work on thiamine related enzyme
mimics will also be pursued, as will work on the synthesis and study of the
hydrophobic cage molecules. Design of these syst;ems will be assisted by
computer modeling methods. Work will be pursued on the design of catalysts
that cleave RNA, using a newly developed assay technique. Studies of the
catalysis of Diels-Alder reactions and related processes by hydrophobic
effects and cage catalysts will be pursued, emphasizing selectivity. Work
will also be directed at producing good mimics of peptide-cleaving and
synthesizing enzymes.
Status | Finished |
---|---|
Effective start/end date | 1/1/86 → 6/30/96 |
Funding
- National Institute of General Medical Sciences
ASJC Scopus Subject Areas
- Biochemistry
- Catalysis
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