BIOCHEMICAL MODEL REACTIONS

  • Breslow, Ronald C. (PI)

Projet

Détails sur le projet

Description

Work on artificial enzymes will be pursued. This includes compounds combining cyclodextrins, pyridoxal or pyridoxamine with binding groups, such as cyclodextrins, macrocycles, or steroids; appropriate placement of basic catalytic groups will also be used to promote specific processes. The characteristic specificities of enzyme reactions--for substrate, for chemical reaction, for region of the substrate, and for stereochemistry of substrate and produce--will be mimicked. Work on thiamine related enzyme mimics will also be pursued, as will work on the synthesis and study of the hydrophobic cage molecules. Design of these syst;ems will be assisted by computer modeling methods. Work will be pursued on the design of catalysts that cleave RNA, using a newly developed assay technique. Studies of the catalysis of Diels-Alder reactions and related processes by hydrophobic effects and cage catalysts will be pursued, emphasizing selectivity. Work will also be directed at producing good mimics of peptide-cleaving and synthesizing enzymes.
StatutTerminé
Date de début/de fin réelle1/1/866/30/96

Financement

  • National Institute of General Medical Sciences

Keywords

  • Bioquímica
  • Catálisis

Empreinte numérique

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