TY - JOUR
T1 - An immunogenetically defined and immunodominant Trypanosoma cruzi antigen
AU - Ramos, R.
AU - Juri, M.
AU - Ramos, A.
AU - Hoecker, G.
AU - Lavandero, S.
AU - Pena, P.
AU - Morello, A.
AU - Repetto, Y.
AU - Aguillon, J. C.
AU - Ferreira, A.
PY - 1991
Y1 - 1991
N2 - Two strains of mice, A. SW (H-2(s)) and A.CA (H-2(f)), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from A.SW mice, but not from A.CA, recognized, in an immunodominant fashion, a 45 kDal polypeptide (Tc45) present in both epimastigotes and trypomastigotes. Since A.SW and A.CA strains are congenic for the major histocompatibility H-2 complex, recognition of Tc45 seems to be controlled by this genetic region or by gene(s) located in its immediate vicinity. Subcellular fractionation revealed that Tc45 is mainly present at the cytoplasmic compartment.
AB - Two strains of mice, A. SW (H-2(s)) and A.CA (H-2(f)), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from A.SW mice, but not from A.CA, recognized, in an immunodominant fashion, a 45 kDal polypeptide (Tc45) present in both epimastigotes and trypomastigotes. Since A.SW and A.CA strains are congenic for the major histocompatibility H-2 complex, recognition of Tc45 seems to be controlled by this genetic region or by gene(s) located in its immediate vicinity. Subcellular fractionation revealed that Tc45 is mainly present at the cytoplasmic compartment.
UR - http://www.scopus.com/inward/record.url?scp=0025732335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025732335&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.1991.44.314
DO - 10.4269/ajtmh.1991.44.314
M3 - Article
C2 - 2035753
AN - SCOPUS:0025732335
SN - 0002-9637
VL - 44
SP - 314
EP - 322
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -
