Autophagy in cardiovascular biology

Sergio Lavandero; Mario Chiong; Beverly A. Rothermel; Joseph A. Hill

doi:10.1172/JCI73943

Autophagy in cardiovascular biology

Sergio Lavandero, Mario Chiong, Beverly A. Rothermel, Joseph A. Hill

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

272 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.

Original language	English
Pages (from-to)	55-64
Number of pages	10
Journal	Journal of Clinical Investigation
Volume	125
Issue number	1
DOIs	https://doi.org/10.1172/JCI73943
Publication status	Published - Jan 2 2015

Funding

Funders	Funder number
National Institutes of Health	HL-097768, HL-120732
National Heart, Lung, and Blood Institute	U01HL100401

ASJC Scopus Subject Areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1172/JCI73943

Cite this

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Autophagy in cardiovascular biology

Abstract

Funding

ASJC Scopus Subject Areas

UN SDGs

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