Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat

Jorge E. Jalil; Roberto Ebensperger; Jaime Meléndez; Erika Acevedo; Mario Sapag-Hagar; Fabían González-Jara; Anita Gálvez; Viviana Pérez-Montes; Sergio Lavandero

doi:10.1016/S0024-3205(99)00097-1

Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat

Jorge E. Jalil, Roberto Ebensperger, Jaime Meléndez, Erika Acevedo, Mario Sapag-Hagar, Fabían González-Jara, Anita Gálvez, Viviana Pérez-Montes, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.

Original language	English
Pages (from-to)	1603-1612
Number of pages	10
Journal	Life Sciences
Volume	64
Issue number	18
DOIs	https://doi.org/10.1016/S0024-3205(99)00097-1
Publication status	Published - Mar 26 1999

Bibliographical note

Funding Information:
We thank to Professor C.I. Pogson for his critical review of the manuscript. This work was supportedin part by Fondo NacionaI de Ciencia y Tecnologia (FONDECYT) Grants 1930592a nd 1950452.

Funding

We thank to Professor C.I. Pogson for his critical review of the manuscript. This work was supportedin part by Fondo NacionaI de Ciencia y Tecnologia (FONDECYT) Grants 1930592a nd 1950452.

Funders	Funder number
Fondo Nacional de Ciencia y Tecnología	1950452

ASJC Scopus Subject Areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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Cite this

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title = "Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat",

abstract = "There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.",

author = "Jalil, {Jorge E.} and Roberto Ebensperger and Jaime Mel{\'e}ndez and Erika Acevedo and Mario Sapag-Hagar and Fab{\'i}an Gonz{\'a}lez-Jara and Anita G{\'a}lvez and Viviana P{\'e}rez-Montes and Sergio Lavandero",

note = "Funding Information: We thank to Professor C.I. Pogson for his critical review of the manuscript. This work was supportedin part by Fondo NacionaI de Ciencia y Tecnologia (FONDECYT) Grants 1930592a nd 1950452.",

year = "1999",

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doi = "10.1016/S0024-3205(99)00097-1",

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AU - Jalil, Jorge E.

AU - Ebensperger, Roberto

AU - Meléndez, Jaime

AU - Acevedo, Erika

AU - Sapag-Hagar, Mario

AU - González-Jara, Fabían

AU - Gálvez, Anita

AU - Pérez-Montes, Viviana

AU - Lavandero, Sergio

N1 - Funding Information: We thank to Professor C.I. Pogson for his critical review of the manuscript. This work was supportedin part by Fondo NacionaI de Ciencia y Tecnologia (FONDECYT) Grants 1930592a nd 1950452.

PY - 1999/3/26

Y1 - 1999/3/26

N2 - There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.

AB - There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.

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Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat

Abstract

Bibliographical note

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