TY - JOUR
T1 - Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
AU - Jalil, Jorge E.
AU - Ebensperger, Roberto
AU - Meléndez, Jaime
AU - Acevedo, Erika
AU - Sapag-Hagar, Mario
AU - González-Jara, Fabían
AU - Gálvez, Anita
AU - Pérez-Montes, Viviana
AU - Lavandero, Sergio
N1 - Funding Information:
We thank to Professor C.I. Pogson for his critical review of the manuscript. This work was supportedin part by Fondo NacionaI de Ciencia y Tecnologia (FONDECYT) Grants 1930592a nd 1950452.
PY - 1999/3/26
Y1 - 1999/3/26
N2 - There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.
AB - There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and α-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, α-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.
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U2 - 10.1016/S0024-3205(99)00097-1
DO - 10.1016/S0024-3205(99)00097-1
M3 - Article
C2 - 10328520
AN - SCOPUS:0033605841
SN - 0024-3205
VL - 64
SP - 1603
EP - 1612
JO - Life Sciences
JF - Life Sciences
IS - 18
ER -