Heart energy metabolism and its role in the treatment of heart failure

Pablo Castro; Luigi Gabrielli; Hugo Verdejo; Douglas Greig; Rosemarie Mellado; Roberto Concepción; Luis Sepúlveda; José Luis Vukasovic; Lorena García; Marcela Pizarro; Deisy Pivet; Constanza Carrillo; Fabiola Tapia; Mario Navarro; Rodrigo Troncoso; Fernando Baraona; Silvana Llevaneras; Claudia Hernández; Iván Godoy; Jorge E. Jalil; Juan Carlos Quintana; Pilar Orellana; Mario Chiong; Sergio Lavandero

Heart energy metabolism and its role in the treatment of heart failure

Pablo Castro, Luigi Gabrielli, Hugo Verdejo, Douglas Greig, Rosemarie Mellado, Roberto Concepción, Luis Sepúlveda, José Luis Vukasovic, Lorena García, Marcela Pizarro, Deisy Pivet, Constanza Carrillo, Fabiola Tapia, Mario Navarro, Rodrigo Troncoso, Fernando Baraona, Silvana Llevaneras, Claudia Hernández, Iván Godoy, Jorge E. JalilJuan Carlos Quintana, Pilar Orellana, Mario Chiong, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.

Translated title of the contribution	Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Original language	English
Pages (from-to)	1028-1039
Number of pages	12
Journal	Revista Medica de Chile
Volume	138
Issue number	8
Publication status	Published - Aug 2010

ASJC Scopus Subject Areas

General Medicine

Cite this

Castro, P., Gabrielli, L., Verdejo, H., Greig, D., Mellado, R., Concepción, R., Sepúlveda, L., Vukasovic, J. L., García, L., Pizarro, M., Pivet, D., Carrillo, C., Tapia, F., Navarro, M., Troncoso, R., Baraona, F., Llevaneras, S., Hernández, C., Godoy, I., ... Lavandero, S. (2010). Heart energy metabolism and its role in the treatment of heart failure. Revista Medica de Chile, 138(8), 1028-1039.

Castro, P, Gabrielli, L, Verdejo, H, Greig, D, Mellado, R, Concepción, R, Sepúlveda, L, Vukasovic, JL, García, L, Pizarro, M, Pivet, D, Carrillo, C, Tapia, F, Navarro, M, Troncoso, R, Baraona, F, Llevaneras, S, Hernández, C, Godoy, I, Jalil, JE, Quintana, JC, Orellana, P, Chiong, M & Lavandero, S 2010, 'Heart energy metabolism and its role in the treatment of heart failure', Revista Medica de Chile, vol. 138, no. 8, pp. 1028-1039.

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abstract = "It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.",

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AU - Verdejo, Hugo

AU - Greig, Douglas

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AU - Concepción, Roberto

AU - Sepúlveda, Luis

AU - Vukasovic, José Luis

AU - García, Lorena

AU - Pizarro, Marcela

AU - Pivet, Deisy

AU - Carrillo, Constanza

AU - Tapia, Fabiola

AU - Navarro, Mario

AU - Troncoso, Rodrigo

AU - Baraona, Fernando

AU - Llevaneras, Silvana

AU - Hernández, Claudia

AU - Godoy, Iván

AU - Jalil, Jorge E.

AU - Quintana, Juan Carlos

AU - Orellana, Pilar

AU - Chiong, Mario

AU - Lavandero, Sergio

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AB - It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.

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Heart energy metabolism and its role in the treatment of heart failure

Abstract

ASJC Scopus Subject Areas

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