TY - JOUR
T1 - Heart energy metabolism and its role in the treatment of heart failure
AU - Castro, Pablo
AU - Gabrielli, Luigi
AU - Verdejo, Hugo
AU - Greig, Douglas
AU - Mellado, Rosemarie
AU - Concepción, Roberto
AU - Sepúlveda, Luis
AU - Vukasovic, José Luis
AU - García, Lorena
AU - Pizarro, Marcela
AU - Pivet, Deisy
AU - Carrillo, Constanza
AU - Tapia, Fabiola
AU - Navarro, Mario
AU - Troncoso, Rodrigo
AU - Baraona, Fernando
AU - Llevaneras, Silvana
AU - Hernández, Claudia
AU - Godoy, Iván
AU - Jalil, Jorge E.
AU - Quintana, Juan Carlos
AU - Orellana, Pilar
AU - Chiong, Mario
AU - Lavandero, Sergio
PY - 2010/8
Y1 - 2010/8
N2 - It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.
AB - It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.
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M3 - Article
C2 - 21140063
AN - SCOPUS:78649249583
SN - 0034-9887
VL - 138
SP - 1028
EP - 1039
JO - Revista Medica de Chile
JF - Revista Medica de Chile
IS - 8
ER -