Castro, P., Gabrielli, L., Verdejo, H., Greig, D., Mellado, R., Concepción, R., Sepúlveda, L., Vukasovic, J. L., García, L., Pizarro, M., Pivet, D., Carrillo, C., Tapia, F., Navarro, M., Troncoso, R., Baraona, F., Llevaneras, S., Hernández, C., Godoy, I., ... Lavandero, S. (2010). Heart energy metabolism and its role in the treatment of heart failure. Revista Medica de Chile, 138(8), 1028-1039.
Heart energy metabolism and its role in the treatment of heart failure. / Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo et al.
En:
Revista Medica de Chile, Vol. 138, N.º 8, 08.2010, p. 1028-1039.
Producción científica › revisión exhaustiva
Castro, P, Gabrielli, L, Verdejo, H, Greig, D, Mellado, R, Concepción, R, Sepúlveda, L, Vukasovic, JL, García, L, Pizarro, M, Pivet, D, Carrillo, C, Tapia, F, Navarro, M, Troncoso, R, Baraona, F, Llevaneras, S, Hernández, C, Godoy, I, Jalil, JE, Quintana, JC, Orellana, P, Chiong, M & Lavandero, S 2010, 'Heart energy metabolism and its role in the treatment of heart failure', Revista Medica de Chile, vol. 138, n.º 8, pp. 1028-1039.
Castro P, Gabrielli L, Verdejo H, Greig D, Mellado R, Concepción R et al. Heart energy metabolism and its role in the treatment of heart failure. Revista Medica de Chile. 2010 ago.;138(8):1028-1039.
Castro, Pablo ; Gabrielli, Luigi ; Verdejo, Hugo et al. / Heart energy metabolism and its role in the treatment of heart failure. En: Revista Medica de Chile. 2010 ; Vol. 138, N.º 8. pp. 1028-1039.
@article{ba648620764749dcab86f4038cf22e26,
title = "Heart energy metabolism and its role in the treatment of heart failure",
abstract = "It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.",
author = "Pablo Castro and Luigi Gabrielli and Hugo Verdejo and Douglas Greig and Rosemarie Mellado and Roberto Concepci{\'o}n and Luis Sep{\'u}lveda and Vukasovic, {Jos{\'e} Luis} and Lorena Garc{\'i}a and Marcela Pizarro and Deisy Pivet and Constanza Carrillo and Fabiola Tapia and Mario Navarro and Rodrigo Troncoso and Fernando Baraona and Silvana Llevaneras and Claudia Hern{\'a}ndez and Iv{\'a}n Godoy and Jalil, {Jorge E.} and Quintana, {Juan Carlos} and Pilar Orellana and Mario Chiong and Sergio Lavandero",
year = "2010",
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AU - Greig, Douglas
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AU - Concepción, Roberto
AU - Sepúlveda, Luis
AU - Vukasovic, José Luis
AU - García, Lorena
AU - Pizarro, Marcela
AU - Pivet, Deisy
AU - Carrillo, Constanza
AU - Tapia, Fabiola
AU - Navarro, Mario
AU - Troncoso, Rodrigo
AU - Baraona, Fernando
AU - Llevaneras, Silvana
AU - Hernández, Claudia
AU - Godoy, Iván
AU - Jalil, Jorge E.
AU - Quintana, Juan Carlos
AU - Orellana, Pilar
AU - Chiong, Mario
AU - Lavandero, Sergio
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AB - It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.
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