Intracellular deoxyribonucleic acid-modifying activity of intermittent phototherapy

Regina M. Santella; Herbert S. Rosenkranz; William T. Speck

doi:10.1016/S0022-3476(78)80616-7

Intracellular deoxyribonucleic acid-modifying activity of intermittent phototherapy

Regina M. Santella, Herbert S. Rosenkranz, William T. Speck

Mailman School of Public Health

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Phototherapy is capable of damaging the genetic material of eukaryotic and prokaryotic cells at fluences considerably less than that received by irradiated infants. It has been suggested that intermittent phototherapy with varying on-off cycles, may offer theoretical advantages since the total light dosage received by the exposed infant is reduced. The present study was undertaken to determine the effect of intermittent phototherapy on the genetic material of human cells in tissue culture. Intermittent illumination produced more DNA damage than a similar light dosage administered continuously. These results suggest that intermittent phototherapy regimens may prove more deleterious to irradiated infants than continuous phototherapy.

Original language	English
Pages (from-to)	106-109
Number of pages	4
Journal	Journal of Pediatrics
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(78)80616-7
Publication status	Published - Jul 1978

Bibliographical note

Funding Information:
From the Department of Microbiolog)" atul Pediatrics, Colh'ge of Physicians and Surgeons. Cohtmbia Universitl, atul Department of Microbiologl, New )'ork Medical College. Presented fit part at the atmual meetblg of the Society for Pediatric Research. San Francisco, California 1977. Supported in part b)" National Institute of Environmental Ilealth Sciences Grant No. IROIES-OI293-OI and National Cancer htstitttte (I-ROI CA 23692-01). *Reprint a&lress: Department of Pediatrics. Rahlbow Babies and Childrens llospitaL Case Western Reserve Universitr. 2101 Adelbert Rd, Clereland. 011 44106.

Funding

From the Department of Microbiolog)" atul Pediatrics, Colh'ge of Physicians and Surgeons. Cohtmbia Universitl, atul Department of Microbiologl, New )'ork Medical College. Presented fit part at the atmual meetblg of the Society for Pediatric Research. San Francisco, California 1977. Supported in part b)" National Institute of Environmental Ilealth Sciences Grant No. IROIES-OI293-OI and National Cancer htstitttte (I-ROI CA 23692-01). *Reprint a&lress: Department of Pediatrics. Rahlbow Babies and Childrens llospitaL Case Western Reserve Universitr. 2101 Adelbert Rd, Clereland. 011 44106.

Funders	Funder number
National Institute of Environmental Ilealth Sciences

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(78)80616-7

Cite this

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title = "Intracellular deoxyribonucleic acid-modifying activity of intermittent phototherapy",

abstract = "Phototherapy is capable of damaging the genetic material of eukaryotic and prokaryotic cells at fluences considerably less than that received by irradiated infants. It has been suggested that intermittent phototherapy with varying on-off cycles, may offer theoretical advantages since the total light dosage received by the exposed infant is reduced. The present study was undertaken to determine the effect of intermittent phototherapy on the genetic material of human cells in tissue culture. Intermittent illumination produced more DNA damage than a similar light dosage administered continuously. These results suggest that intermittent phototherapy regimens may prove more deleterious to irradiated infants than continuous phototherapy.",

author = "Santella, {Regina M.} and Rosenkranz, {Herbert S.} and Speck, {William T.}",

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AU - Rosenkranz, Herbert S.

AU - Speck, William T.

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AB - Phototherapy is capable of damaging the genetic material of eukaryotic and prokaryotic cells at fluences considerably less than that received by irradiated infants. It has been suggested that intermittent phototherapy with varying on-off cycles, may offer theoretical advantages since the total light dosage received by the exposed infant is reduced. The present study was undertaken to determine the effect of intermittent phototherapy on the genetic material of human cells in tissue culture. Intermittent illumination produced more DNA damage than a similar light dosage administered continuously. These results suggest that intermittent phototherapy regimens may prove more deleterious to irradiated infants than continuous phototherapy.

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Intracellular deoxyribonucleic acid-modifying activity of intermittent phototherapy

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

Access to Document

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