Resumen
Phototherapy is capable of damaging the genetic material of eukaryotic and prokaryotic cells at fluences considerably less than that received by irradiated infants. It has been suggested that intermittent phototherapy with varying on-off cycles, may offer theoretical advantages since the total light dosage received by the exposed infant is reduced. The present study was undertaken to determine the effect of intermittent phototherapy on the genetic material of human cells in tissue culture. Intermittent illumination produced more DNA damage than a similar light dosage administered continuously. These results suggest that intermittent phototherapy regimens may prove more deleterious to irradiated infants than continuous phototherapy.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 106-109 |
| Número de páginas | 4 |
| Publicación | Journal of Pediatrics |
| Volumen | 93 |
| N.º | 1 |
| DOI | |
| Estado | Published - jul. 1978 |
Financiación
From the Department of Microbiolog)" atul Pediatrics, Colh'ge of Physicians and Surgeons. Cohtmbia Universitl, atul Department of Microbiologl, New )'ork Medical College. Presented fit part at the atmual meetblg of the Society for Pediatric Research. San Francisco, California 1977. Supported in part b)" National Institute of Environmental Ilealth Sciences Grant No. IROIES-OI293-OI and National Cancer htstitttte (I-ROI CA 23692-01). *Reprint a&lress: Department of Pediatrics. Rahlbow Babies and Childrens llospitaL Case Western Reserve Universitr. 2101 Adelbert Rd, Clereland. 011 44106.
| Financiadores | Número del financiador |
|---|---|
| National Institute of Environmental Ilealth Sciences |
ASJC Scopus Subject Areas
- Pediatrics, Perinatology, and Child Health