Lack of effect of estrogen on rest and treadmill exercise in postmenopausal women without known cardiac disease

Millie Lee; Elsa Grace V. Giardina; Shunichi Homma; Marco R. DiTullio; Robert R. Sciacca

doi:10.1016/S0002-9149(97)00521-3

Lack of effect of estrogen on rest and treadmill exercise in postmenopausal women without known cardiac disease

Millie Lee, Elsa Grace V. Giardina, Shunichi Homma, Marco R. DiTullio, Robert R. Sciacca

School of Nursing

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

To assess the peripheral vascular effects of estrogen in women without coronary disease, normal postmenopausal women (mean age 56 ± 8 years) participated in a randomized, crossover trial using treadmill exercise echocardiography, and received oral conjugated estrogen, 0.625 mg/day or underwent a drug-free period. There was no significant effect on heart rate, blood pressure, double product, left ventricular end-systolic and end- diastolic diameters, or electrocardiographic measures after estrogen. In contrast to the profound effects reported in patients with cardiac disease, oral estrogen in normal women does not bestow significant benefit on treadmill exercise echocardiographic variables at rest or during modest levels of exercise.

Original language	English
Pages (from-to)	793-797
Number of pages	5
Journal	American Journal of Cardiology
Volume	80
Issue number	6
DOIs	https://doi.org/10.1016/S0002-9149(97)00521-3
Publication status	Published - Sept 15 1997

Bibliographical note

Funding Information:
This study was supported in part by Grant HL-07406 from the Department of Health and Human Services, Bethesda, Maryland, Grant RR-00645 from the Research Resources Administration, Bethesda, Maryland, and a Grant from Linda and Peter Nisselson.

Funding

This study was supported in part by Grant HL-07406 from the Department of Health and Human Services, Bethesda, Maryland, Grant RR-00645 from the Research Resources Administration, Bethesda, Maryland, and a Grant from Linda and Peter Nisselson.

Funders	Funder number
Research Resources Administration
U.S. Department of Health and Human Services	RR-00645
National Center for Research Resources	M01RR000645

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(97)00521-3

Cite this

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abstract = "To assess the peripheral vascular effects of estrogen in women without coronary disease, normal postmenopausal women (mean age 56 ± 8 years) participated in a randomized, crossover trial using treadmill exercise echocardiography, and received oral conjugated estrogen, 0.625 mg/day or underwent a drug-free period. There was no significant effect on heart rate, blood pressure, double product, left ventricular end-systolic and end- diastolic diameters, or electrocardiographic measures after estrogen. In contrast to the profound effects reported in patients with cardiac disease, oral estrogen in normal women does not bestow significant benefit on treadmill exercise echocardiographic variables at rest or during modest levels of exercise.",

author = "Millie Lee and Giardina, {Elsa Grace V.} and Shunichi Homma and DiTullio, {Marco R.} and Sciacca, {Robert R.}",

note = "Funding Information: This study was supported in part by Grant HL-07406 from the Department of Health and Human Services, Bethesda, Maryland, Grant RR-00645 from the Research Resources Administration, Bethesda, Maryland, and a Grant from Linda and Peter Nisselson. ",

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AU - DiTullio, Marco R.

AU - Sciacca, Robert R.

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AB - To assess the peripheral vascular effects of estrogen in women without coronary disease, normal postmenopausal women (mean age 56 ± 8 years) participated in a randomized, crossover trial using treadmill exercise echocardiography, and received oral conjugated estrogen, 0.625 mg/day or underwent a drug-free period. There was no significant effect on heart rate, blood pressure, double product, left ventricular end-systolic and end- diastolic diameters, or electrocardiographic measures after estrogen. In contrast to the profound effects reported in patients with cardiac disease, oral estrogen in normal women does not bestow significant benefit on treadmill exercise echocardiographic variables at rest or during modest levels of exercise.

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Lack of effect of estrogen on rest and treadmill exercise in postmenopausal women without known cardiac disease

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

Access to Document

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