New insights into IGF-1 signaling in the heart

Rodrigo Troncoso; Cristián Ibarra; Jose Miguel Vicencio; Enrique Jaimovich; Sergio Lavandero

doi:10.1016/j.tem.2013.12.002

New insights into IGF-1 signaling in the heart

Rodrigo Troncoso, Cristián Ibarra, Jose Miguel Vicencio, Enrique Jaimovich, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

191 Citations (Scopus)

Abstract

Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca²⁺ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.

Original language	English
Pages (from-to)	128-137
Number of pages	10
Journal	Trends in Endocrinology and Metabolism
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.tem.2013.12.002
Publication status	Published - Mar 2014

Bibliographical note

Funding Information:
This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2013.12.002

Cite this

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title = "New insights into IGF-1 signaling in the heart",

abstract = "Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.",

author = "Rodrigo Troncoso and Cristi{\'a}n Ibarra and Vicencio, {Jose Miguel} and Enrique Jaimovich and Sergio Lavandero",

note = "Funding Information: This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.",

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AU - Ibarra, Cristián

AU - Vicencio, Jose Miguel

AU - Jaimovich, Enrique

AU - Lavandero, Sergio

N1 - Funding Information: This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.

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N2 - Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.

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New insights into IGF-1 signaling in the heart

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

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