New insights into IGF-1 signaling in the heart

Rodrigo Troncoso, Cristián Ibarra, Jose Miguel Vicencio, Enrique Jaimovich, Sergio Lavandero

Research output: Contribution to journalReview articlepeer-review

193 Citations (Scopus)

Abstract

Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalTrends in Endocrinology and Metabolism
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 2014

Bibliographical note

Funding Information:
This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.

Funding

This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.

ASJC Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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Troncoso, R., Ibarra, C., Vicencio, J. M., Jaimovich, E., & Lavandero, S. (2014). New insights into IGF-1 signaling in the heart. Trends in Endocrinology and Metabolism, 25(3), 128-137. https://doi.org/10.1016/j.tem.2013.12.002