Abstract
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.
Original language | English |
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Pages (from-to) | 128-137 |
Number of pages | 10 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 25 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2014 |
Bibliographical note
Funding Information:This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.
Funding
This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology