TY - JOUR
T1 - New insights into IGF-1 signaling in the heart
AU - Troncoso, Rodrigo
AU - Ibarra, Cristián
AU - Vicencio, Jose Miguel
AU - Jaimovich, Enrique
AU - Lavandero, Sergio
N1 - Funding Information:
This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.). We thank to R. Bravo-Sagua for his help in the figure design.
PY - 2014/3
Y1 - 2014/3
N2 - Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.
AB - Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=84894364992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894364992&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2013.12.002
DO - 10.1016/j.tem.2013.12.002
M3 - Review article
C2 - 24380833
AN - SCOPUS:84894364992
SN - 1043-2760
VL - 25
SP - 128
EP - 137
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 3
ER -
