Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

Alexander J. Boys; Mary Clare McCorry; Scott Rodeo; Lawrence J. Bonassar; Lara A. Estroff

doi:10.1557/mrc.2017.91

Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

Alexander J. Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J. Bonassar, Lara A. Estroff

Hospital for Special Surgery

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

Original language	English
Pages (from-to)	289-308
Number of pages	20
Journal	MRS Communications
Volume	7
Issue number	3
DOIs	https://doi.org/10.1557/mrc.2017.91
Publication status	Published - Sept 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Materials Research Society.

Funding

The authors acknowledge support from the National Center for Advancing Translational Sciences (NCATS) grant TL1TR000459 of the Clinical and Translational Science Center at Weill Cornell Medical College, and A.J.B. acknowledges a pre-doctoral fellowship award (F31AR070009) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH). The authors would like to thank Leanne Iannucci, Benjamin Cohen, and Jongkil Kim for critical reading of the manuscript and Mary Lou Norman for preparing histological sections.

Funders	Funder number
National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Center for Advancing Translational Sciences	TL1TR000459
Weill Cornell Medical College	F31AR070009
Center for Clinical and Translational Science, Mayo Clinic

ASJC Scopus Subject Areas

General Materials Science

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10.1557/mrc.2017.91

Cite this

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abstract = "Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.",

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Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

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