Résumé
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 289-308 |
| Nombre de pages | 20 |
| Journal | MRS Communications |
| Volume | 7 |
| Numéro de publication | 3 |
| DOI | |
| Statut de publication | Published - sept. 1 2017 |
Financement
The authors acknowledge support from the National Center for Advancing Translational Sciences (NCATS) grant TL1TR000459 of the Clinical and Translational Science Center at Weill Cornell Medical College, and A.J.B. acknowledges a pre-doctoral fellowship award (F31AR070009) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH). The authors would like to thank Leanne Iannucci, Benjamin Cohen, and Jongkil Kim for critical reading of the manuscript and Mary Lou Norman for preparing histological sections.
| Bailleurs de fonds | Numéro du bailleur de fonds |
|---|---|
| National Institutes of Health | |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases | |
| National Center for Advancing Translational Sciences | TL1TR000459 |
| Weill Cornell Medical College | F31AR070009 |
| Center for Clinical and Translational Science, Mayo Clinic |
ASJC Scopus Subject Areas
- General Materials Science