Organelle communication: Signaling crossroads between homeostasis and disease

Roberto Bravo-Sagua; Natalia Torrealba; Felipe Paredes; Pablo E. Morales; Christian Pennanen; Camila López-Crisosto; Rodrigo Troncoso; Alfredo Criollo; Mario Chiong; Joseph A. Hill; Thomas Simmen; Andrew F. Quest; Sergio Lavandero

doi:10.1016/j.biocel.2014.01.019

Organelle communication: Signaling crossroads between homeostasis and disease

Roberto Bravo-Sagua, Natalia Torrealba, Felipe Paredes, Pablo E. Morales, Christian Pennanen, Camila López-Crisosto, Rodrigo Troncoso, Alfredo Criollo, Mario Chiong, Joseph A. Hill, Thomas Simmen, Andrew F. Quest, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Short survey › peer-review

48 Citations (Scopus)

Abstract

Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca²⁺ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/j.biocel.2014.01.019
Publication status	Published - May 2014

Bibliographical note

Funding Information:
This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.

Funding

This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.

Funders	Funder number
AHA-Jon Holden DeHaan Foundation	0970518N
Comision Nacional de Ciencia y Tecnologia
National Institutes of Health	HL-080144, HL-090842
National Heart, Lung, and Blood Institute	R01HL075173
Pew Charitable Trusts
American Heart Association	0640084N
Natural Sciences and Engineering Research Council of Canada	386757-2010
Fondo Nacional de Desarrollo Científico y Tecnológico	1120212, 120003, 15130011, 3130749, ACT1111, 11130285

ASJC Scopus Subject Areas

Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biocel.2014.01.019

Cite this

Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales, P. E., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J. A., Simmen, T., Quest, A. F., & Lavandero, S. (2014). Organelle communication: Signaling crossroads between homeostasis and disease. International Journal of Biochemistry and Cell Biology, 50(1), 55-59. https://doi.org/10.1016/j.biocel.2014.01.019

Bravo-Sagua, R, Torrealba, N, Paredes, F, Morales, PE, Pennanen, C, López-Crisosto, C, Troncoso, R, Criollo, A, Chiong, M, Hill, JA, Simmen, T, Quest, AF & Lavandero, S 2014, 'Organelle communication: Signaling crossroads between homeostasis and disease', International Journal of Biochemistry and Cell Biology, vol. 50, no. 1, pp. 55-59. https://doi.org/10.1016/j.biocel.2014.01.019

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abstract = "Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.",

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note = "Funding Information: This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.",

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AU - Bravo-Sagua, Roberto

AU - Torrealba, Natalia

AU - Paredes, Felipe

AU - Morales, Pablo E.

AU - Pennanen, Christian

AU - López-Crisosto, Camila

AU - Troncoso, Rodrigo

AU - Criollo, Alfredo

AU - Chiong, Mario

AU - Hill, Joseph A.

AU - Simmen, Thomas

AU - Quest, Andrew F.

AU - Lavandero, Sergio

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Organelle communication: Signaling crossroads between homeostasis and disease

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

Access to Document

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Cite this