Organelle communication: Signaling crossroads between homeostasis and disease

Roberto Bravo-Sagua; Natalia Torrealba; Felipe Paredes; Pablo E. Morales; Christian Pennanen; Camila López-Crisosto; Rodrigo Troncoso; Alfredo Criollo; Mario Chiong; Joseph A. Hill; Thomas Simmen; Andrew F. Quest; Sergio Lavandero

doi:10.1016/j.biocel.2014.01.019

Organelle communication: Signaling crossroads between homeostasis and disease

Roberto Bravo-Sagua, Natalia Torrealba, Felipe Paredes, Pablo E. Morales, Christian Pennanen, Camila López-Crisosto, Rodrigo Troncoso, Alfredo Criollo, Mario Chiong, Joseph A. Hill, Thomas Simmen, Andrew F. Quest, Sergio Lavandero

Universidad de Chile

Résultat de recherche › examen par les pairs

48 Citations (Scopus)

Résumé

Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca²⁺ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.

Langue d'origine	English
Pages (de-à)	55-59
Nombre de pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	50
Numéro de publication	1
DOI	https://doi.org/10.1016/j.biocel.2014.01.019
Statut de publication	Published - mai 2014

Financement

This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.

Bailleurs de fonds	Numéro du bailleur de fonds
AHA-Jon Holden DeHaan Foundation	0970518N
Comision Nacional de Ciencia y Tecnologia
National Institutes of Health	HL-080144, HL-090842
National Heart, Lung, and Blood Institute	R01HL075173
Pew Charitable Trusts
American Heart Association	0640084N
Natural Sciences and Engineering Research Council of Canada	386757-2010
Fondo Nacional de Desarrollo Científico y Tecnológico	1120212, 120003, 15130011, 3130749, ACT1111, 11130285

ASJC Scopus Subject Areas

Biochemistry
Cell Biology

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.biocel.2014.01.019

Autres fichiers et liens

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Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales, P. E., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J. A., Simmen, T., Quest, A. F., & Lavandero, S. (2014). Organelle communication: Signaling crossroads between homeostasis and disease. International Journal of Biochemistry and Cell Biology, 50(1), 55-59. https://doi.org/10.1016/j.biocel.2014.01.019

Bravo-Sagua, R, Torrealba, N, Paredes, F, Morales, PE, Pennanen, C, López-Crisosto, C, Troncoso, R, Criollo, A, Chiong, M, Hill, JA, Simmen, T, Quest, AF & Lavandero, S 2014, 'Organelle communication: Signaling crossroads between homeostasis and disease', International Journal of Biochemistry and Cell Biology, vol. 50, n° 1, pp. 55-59. https://doi.org/10.1016/j.biocel.2014.01.019

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title = "Organelle communication: Signaling crossroads between homeostasis and disease",

abstract = "Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.",

author = "Roberto Bravo-Sagua and Natalia Torrealba and Felipe Paredes and Morales, {Pablo E.} and Christian Pennanen and Camila L{\'o}pez-Crisosto and Rodrigo Troncoso and Alfredo Criollo and Mario Chiong and Hill, {Joseph A.} and Thomas Simmen and Quest, {Andrew F.} and Sergio Lavandero",

note = "Funding Information: This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.",

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AU - Bravo-Sagua, Roberto

AU - Torrealba, Natalia

AU - Paredes, Felipe

AU - Morales, Pablo E.

AU - Pennanen, Christian

AU - López-Crisosto, Camila

AU - Troncoso, Rodrigo

AU - Criollo, Alfredo

AU - Chiong, Mario

AU - Hill, Joseph A.

AU - Simmen, Thomas

AU - Quest, Andrew F.

AU - Lavandero, Sergio

N1 - Funding Information: This work was funded by Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile : FONDECYT 1120212 to SL, 11130285 to RT, 3130749 to CP; Anillo ACT1111 to SL, AQ & MC; FONDAP 15130011 to SL, AQ, MC & JAH; JAH; Red Internacional 120003 to SL, AQ, JAH; by the National Institutes of Health (HL-075173, to JAH; HL-080144, to JAH; HL-090842, to JAH), American Heart Association (0640084N, to JAH, 7-08-MN-21-ADA, to JAH), and the AHA-Jon Holden DeHaan Foundation (0970518N, to JAH); Natural Sciences and Engineering Research Council [grant number 386757-2010 ] to TS; and CONICYT PhD fellowships to RB, NT, CLC and FP and Pew Charitable Trust Postdoctoral Fellowship to AC.

PY - 2014/5

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AB - Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.

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Organelle communication: Signaling crossroads between homeostasis and disease

Résumé

Financement

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer