Abstract
Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts used in orthopedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcified fibrocartilage, calcified fibrocartilage, and bone. Regeneration of this multi-tissue interface will be critical for functional graft integration and improving long-term clinical outcome. This review highlights current knowledge of the structure-function relationship at the interface, the mechanism of interface regeneration, and the strategic biomimicry implemented in stratified scaffold design for interface tissue engineering and multi-tissue regeneration. Potential challenges and future directions in this emerging field are also discussed. It is anticipated that interface tissue engineering will lead to the design of a new generation of integrative fixation devices for soft tissue repair, and it will be instrumental for the development of integrated musculoskeletal tissue systems with biomimetic complexity and functionality.
| Original language | English |
|---|---|
| Pages (from-to) | 157-176 |
| Number of pages | 20 |
| Journal | Clinics in Sports Medicine |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2009 |
Bibliographical note
Funding Information:The authors gratefully acknowledge the contribution of all students, fellows, and collaborators who have worked on the orthopedic interface tissue engineering research described in this review. We also thank the National Institutes of Health (NIH/NIAMS AR052402, HHL; AR056459, HHL; and AR055280-A2, HHL/SAR), the Wallace H. Coulter Foundation (HHL/SAR), and the National Science Foundation GK-12 Graduate Fellowship (GK-12 0,338,329, KLM) for funding support.
Funding
The authors gratefully acknowledge the contribution of all students, fellows, and collaborators who have worked on the orthopedic interface tissue engineering research described in this review. We also thank the National Institutes of Health (NIH/NIAMS AR052402, HHL; AR056459, HHL; and AR055280-A2, HHL/SAR), the Wallace H. Coulter Foundation (HHL/SAR), and the National Science Foundation GK-12 Graduate Fellowship (GK-12 0,338,329, KLM) for funding support.
| Funders | Funder number |
|---|---|
| HHL/SAR | |
| NIH/NIAMS | AR056459, AR055280-A2, AR052402 |
| National Science Foundation | GK-12 0,338,329 |
| National Institutes of Health | |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases | R01AR055280 |
| Wallace H. Coulter Foundation |
ASJC Scopus Subject Areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine