TY - JOUR
T1 - Orthopedic Interface Tissue Engineering for the Biological Fixation of Soft Tissue Grafts
AU - Moffat, Kristen L.
AU - Wang, I. Ning Elaine
AU - Rodeo, Scott A.
AU - Lu, Helen H.
N1 - Funding Information:
The authors gratefully acknowledge the contribution of all students, fellows, and collaborators who have worked on the orthopedic interface tissue engineering research described in this review. We also thank the National Institutes of Health (NIH/NIAMS AR052402, HHL; AR056459, HHL; and AR055280-A2, HHL/SAR), the Wallace H. Coulter Foundation (HHL/SAR), and the National Science Foundation GK-12 Graduate Fellowship (GK-12 0,338,329, KLM) for funding support.
PY - 2009/1
Y1 - 2009/1
N2 - Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts used in orthopedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcified fibrocartilage, calcified fibrocartilage, and bone. Regeneration of this multi-tissue interface will be critical for functional graft integration and improving long-term clinical outcome. This review highlights current knowledge of the structure-function relationship at the interface, the mechanism of interface regeneration, and the strategic biomimicry implemented in stratified scaffold design for interface tissue engineering and multi-tissue regeneration. Potential challenges and future directions in this emerging field are also discussed. It is anticipated that interface tissue engineering will lead to the design of a new generation of integrative fixation devices for soft tissue repair, and it will be instrumental for the development of integrated musculoskeletal tissue systems with biomimetic complexity and functionality.
AB - Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts used in orthopedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcified fibrocartilage, calcified fibrocartilage, and bone. Regeneration of this multi-tissue interface will be critical for functional graft integration and improving long-term clinical outcome. This review highlights current knowledge of the structure-function relationship at the interface, the mechanism of interface regeneration, and the strategic biomimicry implemented in stratified scaffold design for interface tissue engineering and multi-tissue regeneration. Potential challenges and future directions in this emerging field are also discussed. It is anticipated that interface tissue engineering will lead to the design of a new generation of integrative fixation devices for soft tissue repair, and it will be instrumental for the development of integrated musculoskeletal tissue systems with biomimetic complexity and functionality.
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U2 - 10.1016/j.csm.2008.08.006
DO - 10.1016/j.csm.2008.08.006
M3 - Review article
C2 - 19064172
AN - SCOPUS:57049160427
SN - 0278-5919
VL - 28
SP - 157
EP - 176
JO - Clinics in Sports Medicine
JF - Clinics in Sports Medicine
IS - 1
ER -