Regulation of cardiomyocyte autophagy by calcium

Soni Shaikh; Rodrigo Troncoso; Alfredo Criollo; Roberto Bravo-Sagua; Lorena García; Eugenia Morselli; Mariana Cifuentes; Andrew F.G. Quest; Joseph A. Hill; Sergio Lavandero

doi:10.1152/ajpendo.00374.2015

Regulation of cardiomyocyte autophagy by calcium

Soni Shaikh, Rodrigo Troncoso, Alfredo Criollo, Roberto Bravo-Sagua, Lorena García, Eugenia Morselli, Mariana Cifuentes, Andrew F.G. Quest, Joseph A. Hill, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

Original language	English
Pages (from-to)	E587-E596
Journal	American Journal of Physiology - Endocrinology and Metabolism
Volume	310
Issue number	8
DOIs	https://doi.org/10.1152/ajpendo.00374.2015
Publication status	Published - Apr 15 2016

Bibliographical note

Publisher Copyright:
© 2016 the American Physiological Society.

Funding

This work was supported by grants from Fondo Nacional de Desarrollo Científico y Tecnológico (grant nos. 11130285 to R. Troncoso, 1140713 to L. Garcia, 1140908 to A. Criollo, and 1150651 to M. Cifuentes and postdoctoral fellowships 3150545 to S. Shaikh and 3160226 to R. Bravo-Sagua), Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (grant no. 15130011 to S. Lavandero, A. Criollo, L. Garcia, R. Troncoso, and A. F. G. Quest), the National Heart, Lung, and Blood Institute (HL-120732 and HL-100401 to J. A. Hill), the American Heart Association (14SFRN20740000 to J. A. Hill), the Cancer Prevention Research Institute of Texas (RP110486P3 to J. A. Hill), and the Leducq Foundation (11CVD04 to J. A. Hill).

Funders	Funder number
National Heart, Lung, and Blood Institute	HL-100401, HL-120732
American Heart Association	14SFRN20740000
Cancer Prevention and Research Institute of Texas	RP110486P3
Fondation Leducq	11CVD04
Fondo Nacional de Desarrollo Científico y Tecnológico	3150545, 3160226, 1140908, 1150651, 11130285, 1140713
Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias	15130011

ASJC Scopus Subject Areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/ajpendo.00374.2015

Cite this

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title = "Regulation of cardiomyocyte autophagy by calcium",

abstract = "Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.",

author = "Soni Shaikh and Rodrigo Troncoso and Alfredo Criollo and Roberto Bravo-Sagua and Lorena Garc{\'i}a and Eugenia Morselli and Mariana Cifuentes and Quest, {Andrew F.G.} and Hill, {Joseph A.} and Sergio Lavandero",

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doi = "10.1152/ajpendo.00374.2015",

language = "English",

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T1 - Regulation of cardiomyocyte autophagy by calcium

AU - Shaikh, Soni

AU - Troncoso, Rodrigo

AU - Criollo, Alfredo

AU - Bravo-Sagua, Roberto

AU - García, Lorena

AU - Morselli, Eugenia

AU - Cifuentes, Mariana

AU - Quest, Andrew F.G.

AU - Hill, Joseph A.

AU - Lavandero, Sergio

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

AB - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

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DO - 10.1152/ajpendo.00374.2015

M3 - Review article

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AN - SCOPUS:84983786855

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SP - E587-E596

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JF - American Journal of Physiology - Endocrinology and Metabolism

IS - 8

ER -

Regulation of cardiomyocyte autophagy by calcium

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

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