Regulation of cardiomyocyte autophagy by calcium

Soni Shaikh; Rodrigo Troncoso; Alfredo Criollo; Roberto Bravo-Sagua; Lorena García; Eugenia Morselli; Mariana Cifuentes; Andrew F.G. Quest; Joseph A. Hill; Sergio Lavandero

doi:10.1152/ajpendo.00374.2015

Regulation of cardiomyocyte autophagy by calcium

Soni Shaikh, Rodrigo Troncoso, Alfredo Criollo, Roberto Bravo-Sagua, Lorena García, Eugenia Morselli, Mariana Cifuentes, Andrew F.G. Quest, Joseph A. Hill, Sergio Lavandero

Universidad de Chile

Producción científica › revisión exhaustiva

10 Citas (Scopus)

Resumen

Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

Idioma original	English
Páginas (desde-hasta)	E587-E596
Publicación	American Journal of Physiology - Endocrinology and Metabolism
Volumen	310
N.º	8
DOI	https://doi.org/10.1152/ajpendo.00374.2015
Estado	Published - abr. 15 2016

Financiación

Financiadores	Número del financiador
National Heart, Lung, and Blood Institute	HL-100401, HL-120732
American Heart Association	14SFRN20740000
Cancer Prevention and Research Institute of Texas	RP110486P3
Fondation Leducq	11CVD04
Fondo Nacional de Desarrollo Científico y Tecnológico	3150545, 3160226, 1140908, 1150651, 11130285, 1140713
Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias	15130011

ASJC Scopus Subject Areas

General Medicine

ODS de las Naciones Unidas

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10.1152/ajpendo.00374.2015

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title = "Regulation of cardiomyocyte autophagy by calcium",

abstract = "Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.",

author = "Soni Shaikh and Rodrigo Troncoso and Alfredo Criollo and Roberto Bravo-Sagua and Lorena Garc{\'i}a and Eugenia Morselli and Mariana Cifuentes and Quest, {Andrew F.G.} and Hill, {Joseph A.} and Sergio Lavandero",

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T1 - Regulation of cardiomyocyte autophagy by calcium

AU - Shaikh, Soni

AU - Troncoso, Rodrigo

AU - Criollo, Alfredo

AU - Bravo-Sagua, Roberto

AU - García, Lorena

AU - Morselli, Eugenia

AU - Cifuentes, Mariana

AU - Quest, Andrew F.G.

AU - Hill, Joseph A.

AU - Lavandero, Sergio

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

AB - Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion channels and exchangers, receptors, and intracellular mediators play fundamental roles. In this review, we discuss calcium-dependent regulation of cardiomyocyte autophagy, a lysosomal mechanism that is often cytoprotective, serving to defend against disease-related stress and nutrient insufficiency. We also highlight the importance of the subcellular distribution of calcium and related proteins, interorganelle communication, and other key signaling events that govern cardiomyocyte autophagy.

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DO - 10.1152/ajpendo.00374.2015

M3 - Review article

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AN - SCOPUS:84983786855

SN - 0193-1849

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SP - E587-E596

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

IS - 8

ER -

Regulation of cardiomyocyte autophagy by calcium

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ASJC Scopus Subject Areas

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