Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Ting Cong; Kyle W. Morse; Branden R. Sosa; Joseph M. Lane; Scott A. Rodeo; Matthew B. Greenblatt

doi:10.2106/JBJS.24.00905

Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Ting Cong, Kyle W. Morse, Branden R. Sosa, Joseph M. Lane, Scott A. Rodeo, Matthew B. Greenblatt

Hospital for Special Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.SSCs express specific combinations of cell surface markers that reflect their lineage identity.SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

Original language	English
Pages (from-to)	418-426
Number of pages	9
Journal	Journal of Bone and Joint Surgery - Series A
Volume	107
Issue number	4
DOIs	https://doi.org/10.2106/JBJS.24.00905
Publication status	Published - Feb 19 2025

Bibliographical note

Publisher Copyright:
© 2024 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED.

ASJC Scopus Subject Areas

Surgery
Orthopedics and Sports Medicine

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10.2106/JBJS.24.00905

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Cong, T., Morse, K. W., Sosa, B. R., Lane, J. M., Rodeo, S. A., & Greenblatt, M. B. (2025). Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair. Journal of Bone and Joint Surgery - Series A, 107(4), 418-426. https://doi.org/10.2106/JBJS.24.00905

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AU - Cong, Ting

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AU - Sosa, Branden R.

AU - Lane, Joseph M.

AU - Rodeo, Scott A.

AU - Greenblatt, Matthew B.

PY - 2025/2/19

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AB - Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.SSCs express specific combinations of cell surface markers that reflect their lineage identity.SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

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Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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