The acquired immunodeficiency syndrome: An ultrastructural study

Gurdip S. Sidhu; Rosalyn E. Stahl; Waffa El-Sadr; Nicholas D. Cassal; Eulee M. Forrester; Susan Zolla-Pazner

doi:10.1016/S0046-8177(85)80231-8

The acquired immunodeficiency syndrome: An ultrastructural study

Gurdip S. Sidhu, Rosalyn E. Stahl, Waffa El-Sadr, Nicholas D. Cassal, Eulee M. Forrester, Susan Zolla-Pazner

Mailman School of Public Health

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.

Original language	English
Pages (from-to)	377-386
Number of pages	10
Journal	Human Pathology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/S0046-8177(85)80231-8
Publication status	Published - Apr 1985

Bibliographical note

Funding Information:
Received from the Departments of *Pathology and tMedicine, New York Veterans Administration Medical Center, and the New york University School of Medicine, New York, New York. Rcvi-gion accepted for pt*blication August 13, 198-1. Supported in part by a grant from the Cancer Research Institute and b)' funds from the Veterans Administration.

Funding

Received from the Departments of *Pathology and tMedicine, New York Veterans Administration Medical Center, and the New york University School of Medicine, New York, New York. Rcvi-gion accepted for pt*blication August 13, 198-1. Supported in part by a grant from the Cancer Research Institute and b)' funds from the Veterans Administration.

Funders	Funder number
Veterans Administration
Cancer Research Institute

ASJC Scopus Subject Areas

Pathology and Forensic Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0046-8177(85)80231-8

Cite this

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title = "The acquired immunodeficiency syndrome: An ultrastructural study",

abstract = "Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.",

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N2 - Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.

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The acquired immunodeficiency syndrome: An ultrastructural study

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

UN SDGs

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