TY - JOUR
T1 - The acquired immunodeficiency syndrome
T2 - An ultrastructural study
AU - Sidhu, Gurdip S.
AU - Stahl, Rosalyn E.
AU - El-Sadr, Waffa
AU - Cassal, Nicholas D.
AU - Forrester, Eulee M.
AU - Zolla-Pazner, Susan
N1 - Funding Information:
Received from the Departments of *Pathology and tMedicine, New York Veterans Administration Medical Center, and the New york University School of Medicine, New York, New York. Rcvi-gion accepted for pt*blication August 13, 198-1. Supported in part by a grant from the Cancer Research Institute and b)' funds from the Veterans Administration.
PY - 1985/4
Y1 - 1985/4
N2 - Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.
AB - Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.
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U2 - 10.1016/S0046-8177(85)80231-8
DO - 10.1016/S0046-8177(85)80231-8
M3 - Article
C2 - 3872253
AN - SCOPUS:0021864171
SN - 0046-8177
VL - 16
SP - 377
EP - 386
JO - Human Pathology
JF - Human Pathology
IS - 4
ER -
