The complex interplay between mitochondrial dynamics and cardiac metabolism

Valentina Parra; Hugo Verdejo; Andrea Del Campo; Christian Pennanen; Jovan Kuzmicic; Myriam Iglewski; Joseph A. Hill; Beverly A. Rothermel; Sergio Lavandero

doi:10.1007/s10863-011-9332-0

The complex interplay between mitochondrial dynamics and cardiac metabolism

Valentina Parra, Hugo Verdejo, Andrea Del Campo, Christian Pennanen, Jovan Kuzmicic, Myriam Iglewski, Joseph A. Hill, Beverly A. Rothermel, Sergio Lavandero

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Journal of Bioenergetics and Biomembranes
Volume	43
Issue number	1
DOIs	https://doi.org/10.1007/s10863-011-9332-0
Publication status	Published - Feb 2011

Bibliographical note

Funding Information:
Acknowledgments This research was funded in part by the Comision Nacional de Ciencia y Tecnologia (FONDECYT 1080436 and FONDAP 15010006 to S.L.), the National Institutes of Health (RO1HL090842, RO1HL080144 and RO1 HL0755173 to J.A.H. and RO1HL072016 and RO1HL097768 to B.A.R.), the American Heart Association (10POST4340064 to M.I., 0640084N to J.A.H., and Gran-in-Aid #0655202Y to B.A.R.), the American Heart Association-Jon Holden DeHaan Foundation (to J.A.H. and B.A.R.). V.P., H.V., J.K., C.P., A.d.C. hold a PhD fellowship from CONICYT, Chile.

Funding

Acknowledgments This research was funded in part by the Comision Nacional de Ciencia y Tecnologia (FONDECYT 1080436 and FONDAP 15010006 to S.L.), the National Institutes of Health (RO1HL090842, RO1HL080144 and RO1 HL0755173 to J.A.H. and RO1HL072016 and RO1HL097768 to B.A.R.), the American Heart Association (10POST4340064 to M.I., 0640084N to J.A.H., and Gran-in-Aid #0655202Y to B.A.R.), the American Heart Association-Jon Holden DeHaan Foundation (to J.A.H. and B.A.R.). V.P., H.V., J.K., C.P., A.d.C. hold a PhD fellowship from CONICYT, Chile.

Funders	Funder number
American Heart Association-Jon Holden DeHaan Foundation
Comision Nacional de Ciencia y Tecnologia
National Institutes of Health	RO1 HL0755173, RO1HL080144, RO1HL072016, RO1HL097768
National Heart, Lung, and Blood Institute	R01HL090842
American Heart Association	10POST4340064, 0655202Y, 0640084N
Comisión Nacional de Investigación Científica y Tecnológica
Fondo Nacional de Desarrollo Científico y Tecnológico	1080436, FONDAP 15010006

ASJC Scopus Subject Areas

Physiology
Cell Biology

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10.1007/s10863-011-9332-0

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abstract = "Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.",

author = "Valentina Parra and Hugo Verdejo and {Del Campo}, Andrea and Christian Pennanen and Jovan Kuzmicic and Myriam Iglewski and Hill, {Joseph A.} and Rothermel, {Beverly A.} and Sergio Lavandero",

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AU - Hill, Joseph A.

AU - Rothermel, Beverly A.

AU - Lavandero, Sergio

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The complex interplay between mitochondrial dynamics and cardiac metabolism

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

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